Copper deficiency decreases complex IV but not complex I, II, III, or V in the mitochondrial respiratory chain in rat heart. J Nutr. 2007;137:14-8.Zeng H, Saari JT, Johnson WT (2007) Copper deficiency decreases complex IV but not complex I, II, III, or V in the mitochondrial ...
She was found to have copper deficiency, underwent IV repletion, prescribed oral repletion, and was discharged home. She subsequently developed progressive symptoms over the following year and remained unable to function at home. Treatment required inpatient copper repletion followed by inpatient ...
Cyto- chrome c oxidase deficiency in Menkes kinky hair disease. Brain Dev 1983;5:533–40. 25. Munakata M, Sakamoto O, Kitamura T,et al. The effects of copper- histidine therapy on brain metabolism in a patient with Menkes dis- ease: a proton magnetic resonance spectroscopic study. Brain ...
Current approaches to addressing copper deficiency rely on universal copper ionophores. Copper ionophores are small molecules that bind to copper and transport it into cells. Notably, the well-known copper ionophore elesclomol, which has selectivity for cancer cells, has been used in clinical trials...
However, Cu deficiency is rare and is mainly restricted to soils that are very high in organic matter that strongly binds Cu. Moreover, Fe may substitute for Cu because the tasks of many Cu proteins can also be carried out by equivalent Fe proteins (Yruela, 2009). In contrast, when ...
This disorder results from mutations in the ATP7A gene present on the X-chromosomes, which causes severe copper deficiency. DBH requires a bound Cu cofactor to catalyze the conversion of DA to NE [27,28]. Furthermore, occipital horn syndrome and isolated distal motor neuropathy are two other ...
3f, g). Together, these data indicated that deficiency of COX17 augments TGF-β1 induced-mitochondrial dysfunction, cell apoptosis and cellular fibrotic changes. Fig. 3: Downregulation of COX17 aggravates TGF-β1 induced-mitochondrial dysfunction and cell apoptosis. a Western blot and b RT-PCR ...
Copper oxide nanoparticles (Nano-CuO) are one of the most produced and used nanomaterials. Previous studies have shown that exposure to Nano-CuO caused acute lung injury, inflammation, and fibrosis. However, the mechanisms underlying Nano-CuO-induced lun
ATP deficiency leads to neuronal cell death. Cuproptosis is considered a critical mechanism of nerve cell death due to its reliance on mitochondrial respiration; however, there is insufficient evidence to support this claim [109]. Huo et al. [110] propose that cuproptosis is the result of non...
Essentially identical treatment for producing iron and copper deficiency had previously been shown to de- plete liver hydrolyzable iron and copper, respectively, in addition to depressing hemoglobin and cytochrome concentrations [7, 10]. Iron-deficient rats in group IIB were repleted by an initial ...