doi:10.1378/chest.08-1419Kazuhiro Ito, PhDFrom Airways Disease SectionPeter J. Barnes, MD, FCCPFrom Airways Disease SectionElsevier Inc.ChestIto K, Barnes PJ. COPD as a disease of accelerated lung aging. Chest 2009;135:173-180.
COPD as a disease of accelerated lung aging. Chest. 2009;135:173–180. doi:10.1378/chest.08-1419 41. MacNee W. Is chronic obstructive pulmonary disease an accelerated aging disease? Ann Am Thorac Soc. 2016;13(Suppl 5):S429–S37. doi:10.1513/AnnalsATS.201602-124AW 42. Rodriguez JM, ...
and chronic obstructive pulmonary disease (COPD) has been described as a disease of accelerated lung aging2. Nicotinamide adenine dinucleotide (NAD+) has emerged as a central molecule involved in multiple age-related pathways, including immune function and inflammation3. Importantly, NAD+modulates DNA ...
The article discusses the role of microRNA as pathogenic link between chronic obstructive pulmonary disease (COPD) and lung cancer. It suggests the involve... JI Shin,GG Brusselle - 《Nature Reviews Cancer》 被引量: 156发表: 2014年 Accelerated lung aging: a novel pathogenic mechanism of chroni...
resubmitted 19th January 2011; revised 14th April 2011; accepted 7th May 2011; online 16th September 2011 Abstract Chronic obstructive pulmonary disease (COPD) has historically been considered a disease of older, white, male smokers, as illustrated in Frank Netter's classic images of the 'pink puf...
Probing the Cellular and Molecular Mechanisms Underlying in the Pathogenesis of Chronic Obstructive Pulmonary Disease Chapter© 2021 Introduction Chronic obstructive pulmonary disease (COPD) is the 3rd leading cause of morbidity and mortality worldwide [1]. It is defined as “a common preventable and...
Little attention has been paid to the pathophysiological changes in the natural history of chronic obstructive pulmonary disease (COPD). The destructions of the small airways were visualized on thoracic micro-computed tomography scan. We investigated whe
"Previous studies have suggested that COPD may be a disease of accelerated aging for a variety of reasons including its close relation to senescence-related disorders, such as osteoporosis and dementia, and its exponential increase in prevalence beyond 50 years of age. One important biomarker of re...
Severedestructionofsmallairwayscanleadtotheformationoflargeairpockets-knownasbullae-thatreplacelungtissue.Thisformofdiseaseiscalledbullousemphysemamicroscope20第二十页,共155页。Dissection21第二十一页,共155页。Alateralchestx-rayofapersonwithemphysema.Notethebarrelchestandflatdiaphragm22第二十二页,共155页。CTimage...
Chronic obstructive pulmonary disease (COPD) management remains challenging due to the high heterogeneity of clinical symptoms and the complex pathophysiological basis of the disease. Airflow limitation, diagnosed by spirometry, remains the cornerstone o