Exposure of pepsinogen to acid for less than 2 min yields a product with proteolytic activity. This activity is due to intramolecular and intermolecular formation of pepsin from pepsinogen. We find no evidence for intermolecular proteolytic activity in the zymogen. These conclusions are based upon two...
VUNAKIS VAN H ET AL: "STRUCTURAL CHANGES ASSOCIATED WITH THE CONVERSION OF PEPSINOGEN TO PEPSIN I.THE N-TERMINAL AMINO ACID RESIDUE AND AMINO ACID COMPOSITION OF THE PEPSIN INHIBITOR" BIOCHIMICA ET BIOPHYSICA ACTA, vol. 22, 1956, pages 537-543, XP000615212 cited in the application...
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CHEMISTRY AND METABOLISM OF MACROMOLECULES: Fluorescent Probes for Conformational States of Proteins: IV. THE PEPSINOGEN-PEPSIN CONVERSION The conversion of pepsinogen to pepsin has been followedby means of the fluorescent probe, Z-p-toluidinonaphthalene-6-sulfonate (TNS). It was found that th......
European Journal of BiochemistryBohak Z. 1973. The kinetics of the conversion of chicken pepsinogen to chicken pepsin. Eur J Biochem 32(3):547-54.Bohak, Z. 1973 Kinetic of conversion of chicken pepsinogen to chicken pepsin. Eur. J. Biochem., 246 : 547-554Bohak, Z. 1973. The kinetics...
The kinetics of the conversion of chicken pepsinogen to chicken pepsin was studied at 25°C by following the appearance of peptic activity using a pH-static method and by following the changes in the fluorescence emission of the protein. It was found that in pH range of 2–4 both processes...
The kinetics of the conversion of chicken pepsinogen to chicken pepsin was studied at 25°C by following the appearance of peptic activity using a pH-static method and by following the changes in the fluorescence emission of the protein. It was found that in pH range of 2–4 both processes...
A spectrophotometric assay of the conversion of pepsinogen into pepsin is described. This assay allows accurate investigations at early stages in the reaction which demonstrate that the conversion is more complex than a simple autocatalytic process and that a unimolecular self activation may also be ...