In particular, it has been rationalized that drugs that act on the ventral hippocampus would be of benefit for treatment of anxiety and depression.18 However the intracellular signalling mechan- isms governing hippocampal neurogenesis have not been widely explored. The c-Jun N-terminal kinases (JNK...
Transport controls for a media devicedoi:WO2008086368 A1Kevin ArnoldRainer BrodersenRachel Clare GoldeenJeffrey MaThomas Michael MaddenJeffrey RobbinWO
This test was performed in the Helsinki mouse behavioural unit using an Activity Monitor system (forFigure 1) modified with a dark box insert that was opaque to visible light and covered half the area of the open field arena (an opening of 5.5 × 7 cm allowed free movement between the ...
Landscape fuel moisture variability can create spatial discontinuity in the availability of fuel that is in the correct state for ignition (surface fuels) and wildfire spread (live fuels), including the potential for spot-fires in extreme conditions, and vulnerability of the organic layer to smolderi...
The most prominent controlling factor is the 500 hPa vertical motion for most basins, except the western North Atlantic, where the relative vorticity in the lower-troposphere plays the dominant role in determining the subseasonal variability of TC genesis36. Motivated by this, we focus on ...
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Problem gamblers demonstrate increased risk taking in probability discount- ing paradigms (Holt et al, 2003; Madden et al, 2009; Petry, 2011). To provide a potent, rapid, and reliable reward that allows for repeated tests of discounting, we employed intracranial self-stimulation (ICSS) as the...
Uncoiling mechanics of Escherichia coli type I fimbriae are optimized for catch bonds. PLoS Biol. 4, e298 (2006). Article PubMed PubMed Central Google Scholar Stewart, E. J., Madden, R., Paul, G. & Taddei, F. Aging and death in an organism that reproduces by morphologically symmetric...
Kidney organogenesis requires the tight control of proliferation, differentiation and apoptosis of renal progenitor cells. How the balance between these cellular decisions is achieved remains elusive. The Wilms’ tumour suppressor Wt1 is required for pro
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