Exclusion criteria were as follows: patients diagnosed as having acute severe illness, severe atopic dermatitis and uncontrolled asthma (baseline FEV1 < 80% of predictive value) according to Japanese pediatric guideline for the treatment and management of bronchial asthm37. Fifty participants were...
This phase III, multicenter, randomized, double-blind, parallel-group study compared the efficacy and safety of nifedipine controlled-release (CR) 40 mg twice daily (b.i.d.) and once daily (q.d.) in 325 Japanese patients with essential hypertension uncontrolled with nifedipine CR 40 mg ...
Headache was the most common adverse event in both groups (40.0% vs 20.8%, respectively, p=0.217).Cilostazol is an effective therapy for patients with VSA uncontrolled by conventional amlodipine therapy, and has no serious side effects.NCT01444885. 展开 ...
et al. Results of a double-blind, randomized, placebo-controlled study of nabiximols oromucosal spray as an adjunctive therapy in advanced cancer patients with chronic uncontrolled pain. J. Pain Symptom Manag. 55, 179–188 (2018). Article Google Scholar Fallon, M. T., Lux, A. E., Mc...
OBJECTIVE: To assess the efficacy and tolerability of adjunctive levetiracetam in patients with uncontrolled generalized tonic-clonic (GTC) seizures associated with idiopathic generalized epilepsies (IGE). METHODS: This multicenter, randomized, double-blind, placebo-controlled, parallel-group study enrolled ...
severe respiratory or gastrointestinal diseases, orthopedic or endocrine diseases; uncontrolled neurological or psychiatric disorder; 3) cancer or infectious diseases, surgery in the 12 months before randomization; 4) pregnant, breast-feeding, or planned pregnancy; 5) used medications or supplements that ...
Sixty-eight treated uncontrolled hypertensive patients (UC: 34; INT: 34) were enrolled. Over the 12-month period, the likelihood of reaching the target BP was higher in the INT group compared to the UC group ( p< 0.05). At 4months, 38% in the INT group reached the target BP vs. ...
Methods This randomized, double-blind, placebo-controlled, multicenter study enrolled patients with uncontrolled POS despite ongoing treatment with 1–2 antiepileptic drugs. Patients exposed to levetiracetam ≤90 days before visit 1 were excluded. Patients entered an 8-week prospective baseline period, ...
before trial recruitment; current uncontrolled heart failure (New York Heart Association classes III and IV); symptomatic and fatal arrhythmia; and significant valvular heart disease. Patients allergic to any of the thiazide drugs were also excluded from the trial....
The reporting was qualitative but referred to target ranges that separate “controlled” PD from “uncontrolled” PD, established by a consensus of a panel of four neurologists experienced in treating PD, then trialled in a previous study4 and subsequently supported by expert panels23,24. The ...