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As a consequence, increasing attention has been focused on methods of giving drugs continually for prolonged time periods and in a controlled fashion. Controlled or sustained release dosage forms provide a therapeutic dose of the drug soon after administration, and then gradually release the drug ...
If nothing is done, the interrelation between addiction and unemployment continues to foster a downward spiral, since ongoing usage may decrease opportunities to reach and keep employment, and unemployment is likely to increase the use of alcohol and drugs. Effective interventions that both prevent ...
As a result, a number of pharmacologically- active purine analogues have been approved for their clinical application as chemotherapeutic agents (antiviral, antiprotozoal, antifungal and anticancer agents13,14) and as pharmacodynamic drugs (coronary vasodilator)15. Therefore, the development of diversity ...
anticholinergics (unless stable dose for X1 month before screening and dose expected to continue unchanged during the study, with minimal EPS), 5-HT3 antagonists, nicotine replacement therapy, smoking cessation medications or remedies, or QT-prolonging drugs, or use of other investigational drug with...
10,13 Despite several treatment options for TSC-associated seizures—including antiepileptic drugs such as vigabatrin, the mTOR inhibitor everolimus, surgical procedures, and dietary therapy14—more than 60% of patients have treatment-resistant epilepsy,13 which is associated with neurodevelopmental ...
The World Health Organization (WHO) has stated that a worldwide failure to provide adequate HIV services for key populations such as men who have sex with men, people in prison, people who inject drugs, sex workers, and transgender people may be a barrier to achieving progress toward ...
A mixed methods evaluation of a peer mentoring intervention in a UK school setting: perspectives from mentees and mentors. Child Youth Serv Rev. 2022;132:106327. Article Google Scholar Parkin S, McKeganey N. The rise and rise of peer education approaches. Drugs Educ Prev Policy. 2000;7:...
Exercise is often defined as an effective complement or alternative to drugs and psychotherapy [20], noted for its high accessibility, acceptability, and safety. Due to its extensive physiological and psychological benefits, the World Health Organization recommends it for diverse populations [21]. Rese...
Medicines for Human Use (Clinical Trials) Amendment (No. 2) Regulations, http://www.legislation.gov.uk/uksi/2006/2984/regulation/2/made (2006). Konrat, C. et al. Underrepresentation of Elderly People in Randomised Controlled Trials. The Example of Trials of 4 Widely Prescribed Drugs. PLoS...