A combination of keywords and MeSH terms was used to identify RCTs on interventions involving AI, for example: “artificial intelligence”, “decision support system”, “deep learning” and “neural network”, in addition to specific terms such as “naïve bayes”, “random forest” and “mu...
The randomisation was stratified according to Child-Pugh class and BCLC stage and it was centralised at the Investigational Drug Service of the Pharmacy of the Bologna center, allocating the first and lowest randomisation code available, and generating the randomisation list....
It is strictly prohibited to release any drugs and their production raw materials, stimulants,control materials or control ingredients, narcotic and calming drugs, psychotropic drugs, toxic drugs for medical use, precursor chemicals, drug rehabilitation drugs and medical institutions preparations and drug...
Ivermectin is an antiparasitic drug indicated for the treatment of intestinal helminths and filariasis in humans and animals [1]. During the Covid-19 pandemic this inexpensive, widely available drug listed in the World Health Organization (WHO) list of essential medicines was tested for repurposing...
The assignment of the causality will be made by the investigator responsible for the care of the participant. An AE whose causal relationship to the study drug or study procedure is assessed by the investigator as “possibly,”“likely,” or “definitely” is an adverse drug reaction, and if...
Peripheral alterations in cytokine and chemokine levels after antidepressant drug treatment for major depressive disorder: systematic review and meta-analysis. Mol Neurobiol. 2018;55(5):4195–206. https://doi.org/10.1007/s12035-017-0632-1. Article PubMed CAS Google Scholar Haq MRU, Kapila R, ...
While the price of OTC drug purchases and the costs to the healthcare system, including the number of doctor’s appointments and associated expenses, are significant, a disproportionate higher cost is incurred from loss of productivity. In the UK, estimates for healthcare and medication costs are...
Witkiewitz K, Marlatt GA: Relapse prevention for alcohol and drug problems: that was Zen, this is Tao. Am Psychol. 2004, 59 (4): 224-235. PubMed Google Scholar Marlatt GA, Donovan D: Relapse prevention: Maintenance strategies in the treatment of addictive behaviors. 2005, New York: Th...
The study was conducted under an investigational new drug application with the Food and Drug Administration under the auspices of NCCAM and registered at clinicaltrials.gov.An interim analysis test for early stopping of the trial for either efficacy or harm was performed when approximately one-half...
A participant will be considered to have withdrawn from the study if he/she does not attend for a study visit after a home visit (done within 1 week of a missed visit) or refuses to take the study drug on two or more occasions without there being a reasonable cause. Participant data...