Incidence and Risk Factors of Stomal Complications in Patients Undergoing Cystectomy With Ileal Conduit Urinary Diversion for Bladder Cancer In this study we examined the incidence and associated factors of stomal complications in patients undergoing radical cystectomy with ileal conduit urinary... E Kou...
Expression of inducible factors reprograms CAR-T cells for enhanced function and safety. Cancer Cell. 2022; 40(12). Huang Z, Wu Y, Allen ME, Pan Y, Kyriakakis P, Lu S, et al. Engineering light-controllable CAR T cells for cancer immunotherapy. Sci Adv. 2020;6(8):eaay9209. Article...
Background: The prognostic implications of the RAS status in colorectal cancer liver metastasis (CRLM) remain unclear. This study investigated the prognostic significance of RAS status after curative hepatectomy, focusing on surgical controllability. Methods: This retrospective study included liver-only ...
interference technology, and more than 98% of small molecule drugs from crossing it to reach the brain cancer site for cancer cell ablation. This makes it difficult to treat brain tumors effectively [10]. Nanotechnology's approach has been shown to enhance the delivery of therapeutic agents to ...
There is a clinical need for new, more effective treatments for chronic and debilitating inflammatory bowel disease (IBD), including Crohn's disease and ul... M Zhang,E Viennois,M Prasad,... - 《Biomaterials》 被引量: 25发表: 2016年 Common colorectal cancer risk variants in SMAD7 are asso...
for electrotransfection at low voltage. Overall, our platform permits simple, efficient, and high-throughput delivery of macromolecules and small molecules into living cells without compromising their viability, which allows for on-chip manipulation, in situ intracellular interrogation and cancer therapy. ...
Cell-based gene therapy for cancer has demonstrated an excellent antitumor effect in many reports. For example, TRAIL, interleukin (IL)-12, IL-27, cytosine deaminase, and oncolytic adenovirus are transduced into MSC to treat cancer. Therefore, the cell-based gene therapy can be applied to vario...
Thus, drug release could be triggered by changes in such factors that are common to cancer cells. However, complete and accelerated release could only be realized when triggered simultaneously by both acidic pH and GSH. Moreover, tests with HepG-2 cells confirmed that folate-receptor mediated ...
The Cre-loxP recombination system is a powerful tool for genetic manipulation. However, there are widely recognized limitations with chemically inducible Cre-loxP systems, and the UV and blue-light induced systems have phototoxicity and minimal capacity
owing to the low and inconsistent energy supply. Here we propose a simplified wearable iontophoresis patch with a built-in Mg battery for efficient and controllable transdermal delivery. This system decreases the system complexity and form factors by using viologen-based hydrogels as an integrated drug...