placeboprinciplesuperiorityuncertaintyThe quest for effective medicines is very old. In modern times two important tools have been developed to evaluate efficacy of' drugs: superiority and non-inferiority types of clinical trials. The former tests the null hypothesis of μ (the difference between a ...
Assessing non‐inferiority of a new treatment in a three‐arm clinical trial including a placebo In non‐inferiority trials, where non‐inferiority of a new experimental drug compared to an active control has to be shown, it may be advisable to use an ... Iris,Pigeot,Juliane,... - 《Sta...
B, The proportion of patients achieving an HbA1c level of less than 7.0% after 26 weeks of treatment was significant for the oral semaglutide 2.5-mg group vs placebo (P = .01) and for all other oral semaglutide dosages and SC semaglutide (P < .001). Missing HbA1c values are...
Objectives: To compare the effects of oral semaglutide with placebo (primary) and open-label subcutaneous semaglutide (secondary) on glycemic control in patients with type 2 diabetes. Design, Setting, and Patients: Phase 2, randomized, parallel-group, dosage-finding, 26-week trial with 5-week ...
Spherical Equivalent Refractive Error (SER) and Axial Length by Treatment Groupa,b View LargeDownload Table 3. Safety Outcomes During the 30-Month Study Perioda View LargeDownload Podcast (13:11) Low-Dose 0.01% Atropine Eye Drops vs Placebo for Myopia Control 1x 0:00 / 0:00 Subscribe to ...
After surgery, the 92 eligible patients were randomized to KT experimental group (n = 46) or placebo control group (n = 46). Standard postoperative analgesia was administered in both groups (paracetamol/non-steroidal anti-inflammatory drugs, epidural analgesia including opioids), with supplemental ...
Safety profiles were similar for both treatment arms except for the higher incidence of flatulence in the acarbose group (28.6% vs. 16.4% for placebo). Adjunctive acarbose therapy offers an efficacious and safe means for improvement of glycemic control in Asian type 2 diabetic patients ...
In hypotension and the plasma arginine vasopressin levels so doing, we hoped to avoid the potential confounding systemic with both the placebo and prazosin, the slope being much effects of systemicblockade. steeper for the prazosin treatment (-1.11) than for the placebo treatment (-0.31). Plasma...
One patient in the placebo group in Study 1 died. As compared with those who received placebo, the patients who received dexamethasone became afebrile earlier (1.6 vs. 5.0 days; P less than 0.001) and were less likely to acquire moderate or more severe bilateral sensorineural hearing loss (...
However, burn children exercised less than nonburn group (21.2 ± 8.6 vs 30 ± 0.0 min; P < .001) and had a lower calculated exercise tolerance index (6.7 ± 4.3 vs 1.0 ± 0.0; P < .01). Burned children had lower peak heart rates than nonburned children (173 ± 13 vs 189 ± ...