Cell Organelles:Cell organelles represent the many smaller membrane-bound objects located within cells. Examples of cell organelles include ribosomes, mitochondria, endoplasmic reticulum, lysosomes, cytoskeleton, and Golgi complex. Each organelle serves a specific function and purpose for the cell....
The nuclei image shows a homogeneous cell density in the center of the EB, while F-actin is homogenous whatever the localization of the cell inside the stretched EB. Scale bar: 100 µm. All EBs were formed with 10,000 ESCs Full size image The magnetic stretcher (Fig. 5a and ...
Formation and maintenance of neuromuscular junctions (NMJs) are essential for skeletal muscle function, allowing voluntary movements and maintenance of the muscle tone, thereby preventing atrophy. Generation of NMJs depends on the interaction of motor ne
An imaging array was located at the center of the therapeutic array for image guidance and treatment planning. The treatment sequence allowed precise targeting to minimize heat deposition outside the treated volume. Before the treatment, a needle thermocouple was inserted next to the tip of the ...
Mechanical forces regulate multiple essential pathways in the cell. The nuclear translocation of mechanoresponsive transcriptional regulators is an essential step for mechanotransduction. However, how mechanical forces regulate the nuclear import process is not understood. Here, we identify a highly mechanoresp...
B. Ueberheide at the NYU Proteomics Resource Center (Cancer Center Support Grant P30CA016087) for mass spectrometry experiments; Igor Dolgarev, Harris Lazaris, and Yixiao Gong for helpful bioinformatic discussions and protocols; and The High Performance Computing Facility of the NYU Center of ...
During chemotaxis, neutrophils use cell surface G Protein Coupled Receptors to detect chemoattractant gradients. The downstream signaling system is wired with multiple feedback loops that amplify weak inputs and promote spatial separation of cell fr
3h,i). We used this system to probe the gene expression response to the induction of SHH in the center of the membrane for a time course of 120 hours, with the PA-Cre–Lox system. Since the RNA capture was not homogeneous, yielding vastly different unique molecular identifier (UMI) ...
Skeletal muscle contains a designated population of adult stem cells, called satellite cells, which are generally quiescent. In homeostasis, satellite cells proliferate only sporadically and usually by asymmetric cell division to replace myofibres damaged by daily activity and maintain the stem cell pool...
Proper regulation of mRNA production in the nucleus is critical for the maintenance of cellular homoeostasis during adaptation to internal and environmental cues. Over the past 25 years, it has become clear that the nuclear machineries governing gene