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CtIP has a key role in DNA double-strand break repair as its role in resecting DNA at the break commits a cell to homologous recombination. Here the authors show that KLHL15 interacts with CtIP and regulates repair by controlling protein turnover. Lorenza P. Ferretti , Sarah-Felicitas Himmels...
Manipulating gene expression in the host genome with high precision is crucial for controlling cellular function and behavior. Here, we present a precise, non-invasive, and tunable strategy for controlling the expression of multiple endogenous genes both
(1996). Cell cycle control of DNA replication. Science 274, 1659 - 1664.Stillman,B. (1996) Cell cycle control of DNA replication. Science, 274, 1659-1664.Stillman, B. 1996. Cell cycle control of DNA replication. Sci- ence 274: 1659-1663....
Serum ccf-DNA has recently emerged as a promising new indicator of the degree of the cell damage. Qualitative and quantitative testing of ccf-DNA can be applied for the management of malignant and benign neoplasia. The purpose of this study was to compare the serum ccf-DNA levels between brea...
Our analysis of the human ACHE-S gene shows it contains several plant RNA processing signals that theoretically could lead to the production of truncated, presumably inactive, AChE. However, removing these sequences in hACHE-S (pTM167, pTM165 and pTM164) or their reintroduction into the oACHES...
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Skeletal muscle contains a designated population of adult stem cells, called satellite cells, which are generally quiescent. In homeostasis, satellite cells proliferate only sporadically and usually by asymmetric cell division to replace myofibres damaged by daily activity and maintain the stem cell pool...
During chemotaxis, neutrophils use cell surface G Protein Coupled Receptors to detect chemoattractant gradients. The downstream signaling system is wired with multiple feedback loops that amplify weak inputs and promote spatial separation of cell fr