Shortly after the initial finding by the Millers (Miller and Miller, 1947; Miller et al., 1949) that the administration of N,N-dimethyl-4-aminoazobenzene (DAB) to rats resulted in the covalent binding of metabolites of the azo-dye to liver proteins, there was considerable interest in the ...
Glenstrup. Program generation, termination, and binding-time analysis. In ICFP '02 : Proceedings of the seventh ACM SIGPLAN international conference on Functional programming, pages 283-283, New York, NY, USA, 2002. ACM Press.N. D. Jones, A. Glenstrup. Program generation, termination, and...
RNA-binding proteins (RBPs) play key roles in post-transcriptional regulation and disease. Their binding sites cover more of the genome than coding exons; nevertheless, most noncoding variant prioritization methods only focus on transcriptional regulation. Here, we integrate the portfolio of ENCODE-...
main proteasedrug repurposingrandom forestbinding activitypredictive modelThe coronavirus disease 2019 (COVID-19) global pandemic resulted in millions of people becoming infected with the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) virus and close to seven million de...
Alchemical transformations where each Pi group of pomotrelvir was transformed into its counterpart in nirmatrelvir were performed to unravel the individual contribution of each group to the binding and reaction processes. We have shown that while a γ‐lactam ring is preferred at ...
From interpreting to compiling binding times - Consel, Danvy - 1990 () Citation Context ...preter-n := specializer(interpreter-1,program-3) 1 Several other approaches include handwriting a specializer generator [23, 28] and performing more operations statically prior to specialization time =-=[...
1989. Binding time analysis for polymorphically typed higher order languages. In TAPSOFT '89, J. D´iaz and F. Orejas, Eds. Number 351,352 in Lecture Notes in Computer Science. Springer-Verlag, Barcelona, Spain, II, 298-312.T. Æ. Mogensen. Binding Time Analysis for Polymorphically ...
Moreover, we employed Molecular Mechanics Generalized Born Surface Area (MM-GBSA) calculations on all "protein-ligand" complexes, underscoring the robust binding capabilities of rosmarinic acid, curcumin, and quercetin against Mpro, and salvianolic acid b, rosmarinic acid, and quercetin towa...
There has been a great deal of research on programming languages for computing with binding and scope (bound variables, 伪 -equivalence, capture-avoiding substitution). These languages are useful for a variety of tasks, such as implementing domain-specific languages and formalizing the metatheory of...
In molecular docking the structure of the binding site is used as a template for the design of new ligands using computational methods whereas in fragment screening biophysical methods are used for the detection of weak binding ligands which are subsequently elaborated into tighter binding molecules. ...