EH domains are relatively short, evolutionarily conserved sequences that were first identified in EPS15 (hence their name; Refs. 37, 38, 39). EPS15 directly binds to the clathrin assembly protein complex AP2 (47
The finding of a range of T cell defects further supported impaired function of the Coro1aLmb3 mutant. In the thymus, DN and double positive ([DP] CD4+CD8+) populations were unaffected. However, there was a variable reduction in the number of single positive (SP) CD4+ and CD8+ thymocyte...
Unlike other myeloid inhibitor receptors such as Fc蔚RIIB [20, 21], gp49B1 =-=[22, 23]-=-, paired Ig-like receptor-B [24, 25], and mast cell function-associated antigen [26, 27], CD200R lacks an ITIM but contains three tyrosine residues in the cytoplasmic domain. One tyrosine (...
The presence of this signal could indicate a novel and yet undescribed function of rhabdoviral N proteins potentially involved in altering host-cell metabolism. The NGAV N protein also possesses a sequence (GLSNRSPYSA) highly conserved with the G(L/I)SXKSPYSS RNA binding motif present in the...
Only messenger RNAs (mRNAs) and long, i.e., larger than 200 nucleotides [41–43], noncoding RNAs are of concern, while those short RNAs that are generally esteemed to function as regulatory elements of genes are left out, in part because we are not aware of any chimeric short regulatory...
This study shows that these anti-CP mAbs will be valuable research tools for further investigating the structure and function of the CHIKV CP. Keywords: chikungunya virus; monoclonal antibodies; capsid protein; epitope mapping; linear B cell epitope; C-terminus; N-terminus 1. Introduction Alpha...
The ATU provides interface for the RAID Controller PCI function. The ATU supports transactions between PCI address space and the 81341 and 81342 I/O Processors address space. Address translation is controlled through programmable registers accessible from both the PCI interface and the Intel...
Anti-αv (L230) has been shown to block the function of all αv integrins (26). The anti-αv (LM142) (30) was provided by Dr. Cheresh. Anti-αIIbβ3 antibody (D57) (32) was provided by Dr. Mark Ginsburg. Anti-α6 (JIB5) is a mouse monoclonal antibody that has been ...