athe assessment of the genotoxic potential of a chemical determins the ability of the chemical to induce changes in a cell's DNA as a consequence of gene mutation. chromosome damage or alteration that mutation is a key event in carcinogenesis. 作为基因突变结果,对genotoxic潜力的评估化工determins化...
Dual consequence of mutation in the dihydrofolate reductase gene of Diplococcus pneumoniae. Biochem Biophys Res Commun. 1969 Aug 15; 36 (4):603–607.Sirotnak, F. M. 1969. Dual consequence of mutation in the dihydrofolate reductase gene of Diplococcus pneumoniae. Biochem. Biophys. Res. Comm. ...
Describes an elegant method for the production of recombinant histones with site-specific acetylations and reveals effects of H3K56ac on DNA breathing. Article CAS PubMed PubMed Central Google Scholar Verdin, E. & Ott, M. 50 years of protein acetylation: from gene regulation to epigenetics, ...
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To investigate mechanisms of DNA mutagenesis, we perform mutation accumulation sequencing experiments with DNA repair defective nematodes: after propagating animals for 40–60 generations (Supplementary Table3), their 100 million base pair (bp)-sized genomes28are sequenced. Unique mutations that arise in...
This chapter explores various consequence-based arguments on the ethics of germline gene editing. First, the chapter distinguishes between descriptive and normative consequence arguments. Second, it takes a deep dive into arguments related to risks and safety, on the one hand, and into arguments rela...
Watson JD, Baker TA, Bell SP, et al. Molecular Biology of the Gene, 6th edn. Pearson Education Inc., UK; 2008 Google Scholar Lee H-C, Wei Y-H. Mitochondrial DNA mutation, oxidative stress, and alteration of gene expression in human aging. In: Berdainer CD (eds) Mitochondria in Healt...
Therefore, the DNA of both parents was examined. The father was heterozygous for the 1226G mutation but the mother did not have this abnormality. It was shown that the mother and both daughters had a deletion of the glucocerebrosidase gene: only about one-half of the polymerase chain reaction...
in accordance with a study that found a missense mutation p.LL363LF, located in the EXXXLI motif, which has been linked to human cancer [44]. Seventy-two human STING gene variations are found in a variety of malignancies, the majority of which are dominant-negative mutants. Further proximi...
An analysis of human cancer exomes revealed an increased prevalence of mutations in thePOLEgene encoding Pol ε in a subset of colorectal and endometrial tumors with a very high mutation load10,11,12,13. The most prevalent change was the replacement of P286 by arginine, and several other subs...