Connexin43 Gene Transfer Reduces Ventricular Tachycardia Susceptibility After Myocardial Infarction Objectives: The aim of this study was to evaluate the links between connexin43 (Cx43) expression, myocardial conduction velocity, and ventricular tachycard... ID Greener,T Sasano,X Wan,... - Journal of...
Cardiac macrophages contribute to different aspects of cardiac function and show highly dynamic gene expression patterns and tissue composition13. The contribution of macrophages to the electrophysiological function of the normal heart is beginning to be elucidated14. However, the direct contribution of ...
Differential changes in gene expression were then analyzed using GeneSifter software. Results: Expression of Cx43 was measured with a mean intensity of 17.0 卤 1.doi:10.1016/j.cardfail.2008.06.426Eric A. YoungRonald ZoltyAndreas BriekeChristopher Stees...
The human connexin 43 gene, or GJA1, is located at human chromosome 6q22-q23 within the candidate region for the oculodentodigital dysplasia locus. This autosomal dominant syndrome presents with craniofacial (ocular, nasal, and dental) and limb dysmorphisms, spastic paraplegia, and ...
We hypothesize electrotonic conduction occurs across non-myocyte gaps in the heart and is partly mediated by Connexin43 (Cx43). We investigated whether non-myocytes in ventricular scar tissue are electrically connected to surrounding myocardial tissue in wild type and fibroblast-specific protein-1 ...
Gap junctions form the cell–cell pathways for propagation of the precisely orchestrated patterns of current flow that govern the regular rhythm of the healthy heart. As in most tissues and organs, multiple connexin types are expressed in the heart; Cx43
Condorelli DF, Parenti R, Spinella F, Trovato-Salinaro A, Belluardo N, Cardile V, Cicirata F: Cloning of a new gap junction gene (Cx36) highly expressed in mammalian brain neurons. Eur J Neurosci. 1998, 10 (3): 1202-8. 10.1046/j.1460-9568.1998.00163.x. CAS PubMed Google Scholar...
JNK activation downregulates the protein level of Cx43 via c-jun suppressed transcriptional activity of the Cx43 gene promoter. Also, some other transcription factors were reported to induce AF through regulating the expression of atrial connexins.29,32 However, the modulation of atrial gap junction...
Endothelium-specific replacement of the connexin43 coding region by a lacZ reporter gene. Genesis 29, 1–13, doi: 10.1002/1526-968x(200101)29:1<1:Aid-Gene1000>3.0.Co;2-0 (2001). Article CAS PubMed Google Scholar Schneider, M. et al. S100A4 is upregulated in injured ...
Connexins are also implicated in the carcinogenic process, where disruption of normal connexin functions is a hallmark of many tumors [12]. As such, multiple human breast tumor cell lines exhibit down-regulation of connexin gene expression [230], and deficiency of Cx43 gap junctions is considered...