Nowadays, around 700,000 deaths per year are globally associated with AMR in bacteria, and this figure is predicted to increase to up to 10 million deaths in 2050 (O'Neill, 2014). There is a growing concern over the possibility of AMR transmission via the food chain (Oniciuc et al., ...
In experimental infections the phenomenon of the lysis of symbiotic bacteria (SB) in the host-cell nucleus was discovered for the first time. Light optical investigations were made of 308 possible combinations of experimental infections of 44 clones of originally symbiont-free Paramecium bursaria by ...
Pathogens such as bacteria and parasites exhibit specific glycan structures on their surface1. These accessible bio- molecules are targets for pathogen specific vaccination. Glycoconjugate vaccines that combine a glycan antigen with a carrier protein have for the most part replaced polysaccharide vaccines ...
1. The enzymatic cascade that results in protein ubiquitylation and degradation involves several distinct steps, each requiring a different class of enzyme. In the first step, an E1 activating enzyme (primarily ubiquitin-activating enzyme (UAE; also known as UBA1), although ubiquitin-like modifier ...
in bacteria, fungi, yeast, or mammalian cell cultures. Furthermore, it will in many cases not be possible to find polypeptides of human origin with the desired properties, wherefore other origin has to be considered. This can be either human polypeptides that are altered in one or more ...
Vaccines based on the cell surface carbohydrates of pathogenic bacteria An Acad Bras Cienc, 77 (2005), pp. 293-324 View in Scopus Google Scholar [15] P. Costantino, R. Rappuoli, F. Berti The design of semi-synthetic and synthetic glycoconjugate vaccines ...
The capsular saccharides of bacteria have been used for many years in vaccines against capsulated bacteria. As saccharides are T-independent antigens, however, they are poorly immunogenic. Conjugation to a carrier can convert T-independent antigens into T-dependent antigens, thereby enhancing memory ...
improvementindissoIution,emuIsification,antioxidationandantibacteriaI.TheappIicationofconjugationofprotein poIysaccharideswassummedup. KeywordsProtein;PoIysaccharide;Conjugation 蛋白质和多糖是食品原料中重要的两类生物大分子,是 影响食品质构的主要因素。蛋白质多糖形成网状复合结构 ...
They found a virulent subset of bacteria Staphylococcus aureus that can establish infection even in the presence of antibiotics vancomycin. They prepared an AAC in which an anti-S. aureus antibody was conjugated to a highly efficacious antibiotics rifalogue that is activated only after being released...
(s). Antibodies used in the present invention may be directed against, for example, tumors, bacteria, fungi, viruses, parasites, mycoplasma, differentiation and other cell membrane antigens, pathogen surface antigens, toxins, enzymes, allergens, drugs and any biologically active molecules. For a ...