In certain embodiments, the reaction between the nucleophile and the vinyl-ether group-containing acrylic ester is conducted in the presence of a catalyst, such as potassium carbonate or any non-nucleophilic base, such as a hindered amine base catalyst. The amount of catalyst used can be whatever...
We report Michael addition products between primary amines and activated α,β-unsaturated compounds exemplified by diethyl methylenemalonate (DEMM). In various embodiments, the reaction proceeds with high yields in the absence of strong base or Lewis acid catalyst under mild reaction conditions. ...
Hatano, M., et al. “Chiral lithium salts of phosphoric acids as Lewis acid—base conjugate catalysts for the enantioselective cyanosilylation of ketones.” Advanced Synthesis & Catalysis 350.11-12 (2008): 1776-1780. Hatano, M., et al. “Which is the actual catalyst: chiral phosphoric Acid ...
Enantioselective addition of diethyl malonate to nitrostyrene and para -chloronitrostyrene is catalyzed by cobalt and manganese complexes with N,N ′-diben... AN Reznikov,EV Golovin,YN Klimochkin - 《Russian Journal of General Chemistry》 被引量: 7发表: 2012年 ...
We report Michael addition products between primary amines and activated α,β-unsaturated compounds exemplified by diethyl methylenemalonate (DEMM). In various embodiments, the reaction proceeds with high yields in the absence of strong base or Lewis acid catalyst under mild reaction conditions. ...
One would envisage that this Lewis acid nucleophile activation mode could be combined with the Brønsted acid activation mode of an electrophile to provide an alternate bifunctional activation mode of guanidines as Brønsted base catalysts (mode IV, Scheme 1). Our DFT study [17] of the ...
Their basic character allows to deprotonate the pro-nucleophile, leading to an enolate which coordinates with the protonated base. Similarly to aldehydes and ketones, if amine-containing bifunctional organocatalysts are employed, the nitro group of the nitroalkene can be also coordinated by means of...