Conformation changes and folding of proteins mediated by Davydov's soliton[J].Physics Letters A,2000,(1-2):124-129.doi:10.1016/S0375-9601(00)00413-8.Shay Caspi and Eshel Ben-Jacob.Conformation changes and folding of proteins mediated by Davydov’s soliton. Physics Letters . 2000...
Thus, the absorption changes observed near 230 mµ for globular proteins result primarily from changes in the environment of the aromatic chromophores indole and phenol. The helix to coil transition and the denaturation-produced solvent perturbation of the amide group must contribute less than 10% ...
Molecular conformation is any spatial arrangement of the atoms in a molecule which can be interconverted by rotations about formally single bonds. Biopolymers, such as polynucleotides, polypeptides or polysaccharides, may change conformation in response to changes in their environment. ...
Therefore, we herein leverage HSA crystal structures to interpret small-angle X-ray scattering (SAXS) data and determine conformational changes of HSA purified from human donors. We show that the HSA dynamicity in solution correlates with the increased level of lipid, bilirubin, and redox state ...
The cholesteryl hemisuccinate treatment also induced conformational changes in the membrane proteins, but did not alter protein composition as shown by SDS-PAGE. The observations collectively indicate that the sterol-induced decrease in bulk lipid fluidity of smooth microsomal membranes accompanying ...
FlexWeb 8 Review … Changes in the shape of the protein occur by changes in dihedral angles of rotatable bonds. Rigidity analysis, using the pebble game and FIRST, determines which dihedral angles are rotatable and which are locked. The rigidity of the three-dimensional folded protein is determi...
In fact, these interactions can modify structure, conformational and physico-chemical properties of proteins, leading to protein functional changes. For example, white grape extracts, green tea extracts, and rosemary extracts have been proven to increase thiol loss in meat protein by forming covalent ...
Accordingly, it is an object of the invention to provide for biosensors that can detect conformational changes that occur in proteins upon binding of ligands on the basis of electron transfer. BRIEF DESCRIPTION OF THE DRAWINGS FIGS. 1A, 1B and 1C schematically depict several embodiments of the ...
The results are therefore consistent with the diffraction changes that implicate helix F in the structural change (Subramaniam et al., 1993) and confirm that the detected opening of the cytoplasmic interhelical region near helix F is the functionally important conforma- tional change in the second ...
Indeed, Pin1-catalyzed conformational changes control many protein functions. Moreover, Pin1 is tightly regulated by multiple mechanisms, and the deregulation of Pin1 plays a pivotal role in some human diseases (e.g., cancer, Alzheimer's disease, and asthma). Given the completely different ...