This treatment is known as the conditioning (or preparative) regimen and is usually assumed to be myeloablative, although this is not always the case. At least in theory, different conditioning regimens may be preferred for different diseases or chosen based upon the source of marrow used for ...
The preparative or conditioning regimen prior to HCT consists of a combination of cytotoxic agents, chemotherapy and serotherapy (antibodies against the host immune system), administered to ablate the bone marrow and the immune system [1]. Fludarabine has been evaluated in various studies as a ...
Intensity of the preparative regimen is an important component of allogeneic transplantations for myelodysplasia (MDS) or acute myelogenous leukemia (AML)... D Lima,M. - 《Blood》 被引量: 1559发表: 2004年 Therapy-related acute myeloid leukemia and myelodysplasia after high-dose chemotherapy and...
We demonstrated previously that a nonmyeloablative preparative regimen can induce mixed chimerism and allograft tolerance in cynomolgus monkeys. Methods. The current studies were designed to clarify the importance and toxicity of various elements of the allotolerance conditioning regimen by: fractionating or...
(HLA)–identical sibling and established the role of TBI as a preparative regimen in this setting.5TBI was administered with a total dose of 10Gy in one fraction using cobalt-60 sources with or without additional systemic therapy. In a follow-up publication, long-term remission was sustained ...
We review the role of pre-transplant conditioning in autologous GM-HCT to enable sufficient long-term engraftment of gene-modified HSCs, promote expression and delivery of therapeutic gene product, and approaches to minimize toxicity related to the preparative regimen. Hematopoietic Stem Cell Gene ...
Our results indicate that TBF is a promising preparative regimen in myelofibrosis patients transplanted from matched sibling or unrelated donors, and should be further explored.doi:10.1038/s41409-019-0653-7Roni ShouvalYakov VegaJoshua A. Fein
360 [][1]Background: The goal of preparative regimen in allogeneic stem cell transplant (allo-SCT) is to eradicate leukemia cells. Relapse remains the majo... C. Benton,M. Konopleva,R. Saliba,... - Blood 被引量: 0发表: 2012年 A trial of plerixafor adjunctive therapy in allogeneic hem...
Thirty-one patients with acute myeloid leukemia which relapsed following conventional therapy (n=15), autologous (n=3), or allogeneic (n=13) HCT were included in a prospective phase I/II trial. The preparative regimen contained 6 and 3 mg/m(2) of GO on days -21 and -14 before ...
Hematopoietic cell transplantation (HCT) is a potentially curative therapeutic procedure in a broad range of malignant and nonmalignant hematological disorders. Conditioning is the preparative regimen that is administered to patients undergoing HCT befor