The poor efficacy of pasireotide in severe hypercortisolism was also demonstrated in a double-blind, phase III study involving 162 adults with Cushing disease [37]. In this clinical trial, severe hypercortisolism, defined by pre-treatment UFC higher than 5 times the ULN, was documented in 61...
There have been two further reports, one involving a patient with cutaneous leishmaniasis (occurring after 19 days of treatment), the second a man with kala-azar (who became thombocytopenic 11 days after starting therapy); in kala-azar a low platelet count is common and the count...
Beyond functional changes, differences in the structural brain integrity, involving both the white and gray matter, which evolve over time, have been reported by several studies between migraine patients and controls. The prevalence and volume of deep white matter lesions is increased in migraine pati...
microRNA-320a prevent Müller cells from hypoxia injury by targeting aquaporin-4. J. Cell Biochem. 121, 4711–4723 (2020). Article CAS PubMed Google Scholar Mao, X. W. et al. Spaceflight induces oxidative damage to blood-brain barrier integrity in a mouse model. FASEB J. 34, 15516–...
Patient was counseled about the possibility of testicular tumor or inflammatory reaction involving the right testicle and inguinal orchiectomy was advised. The patient received antibiotic therapy with ciprofloxacin 1 g/day for 5 days. After informed consent and after preoperative treatment, the patient ...
Meanwhile, some red blood cells in the blood will also enter the ECS through the vascular wall, leading to extravascular hemolysis and the release of a large amount of hemoglobin into the ECS117. Excessive FA has been found in the hippocampus and cerebellum after microgravity stress7. The ...
Scientists have identified molecular signatures in the immune component of the blood which indicate how patients in intensive care with sepsis, septic shock and systemic inflammatory response syndrome are likely to respond to the conditions. The work—led by Public Health England and involving Cardiff ...
Morphological organization of the anterior-mid intestine and histochemical properties of mucins produced by goblet cells The mucosal layers from the anterior-mid intestine of fish fed both experimental diets were similar. In brief, both were lined by a simple columnar epithelium with basal nuclei, bas...
PK15 adapted to tolerate up to 40 mM of heme. An RNA-seq analysis of these heme-adapted PK15 cells (PK15H) revealed a set of altered genes, mainly involved in cell proliferation, metabolism, and inflammation. We found that cytochrome P450, family 1, subfamily A, polypeptide 1 (CYP1A1...
The possibility that other dietary antioxidants, such as polyphenols, may be used to treat obesity and its metabolic complications via mechanisms involving AMPK, MTOR, and autophagy has been recently reviewed by our group [107]. Show moreView chapterExplore book Primary and Secondary Cells K.M. ...