particularly around the issues of patient eligibility and safety. Con-meds are a frequent source of rejection for people wanting to participate in clinical studies. Asystematic reviewof randomized controlled trials identified 54.1% of trials to have at least one medication-related exclusi...
This study suggests the potential of automatically detecting the underreported AE and CM in detail, and it will improve further safety and validity inspections from clinical trials. ABBREVIATIONS: AE, adverse event; ATC, anatomical therapeutic chemical; CM, concomitant medication; EDC, electronic data ...
which may, in turn, lead to the development of the pathological condition of hyponatremia. In severe cases, this condition can result in life-threatening seizures, coma, or death [49]. Clinical case reports report an increased risk of dangerous bronchospasm with ...
Metformin is an oral medication used to treat high glucose levels in patients with type 2 diabetes mellitus. Metformin may: 2.2.2. Obesity and organ transplantations The adiposopathic consequences of obesity promotes the most common metabolic disorders encountered in clinical practice (e.g., diabetes...
Patient: Male, 53 Final Diagnosis: Myocardial infarction Symptoms: Chest pain • tachycardia Medication: — Clinical Procedure: — Specialty: Cardiology ... L Korostovtseva,Y Sviryaev,N Zvartau,... - 《American Journal of Case Reports》 被引量: 7发表: 2014年 Safety of beta-blocker discon...
Between 30% and 70% of patients with breast cancer have pre-existing chronic conditions, and more than half are on long-term non-cancer medication at the time of diagnosis. Preliminary epidemiological evidence suggests that some non-cancer medications ma
Change in spasticity medication or botulinum toxin injection in the upper limb is prohibited during the study. Concomitant care for other issues is permitted. Provisions for post-trial care {30} Participants will be followed up until 1 month post intervention for adverse events. Necessary ...
In randomized, controlled clinical trials, fenoldopam has been found to preserve renal function in situations of potential renal ischemia, such as during radiocontrast administration, cardiac and peripheral vascular surgery, liver transplantation, and treatment of severe hypertension. Fenoldopam...被引...
This increase in medication use is in turn associated with increased morbidity.47 To our knowledge, this is the first study in which the impact of concomitant medications (>3), administration of drugs interfering with CYP3A, antiplatelet, or anticoagulants has been analyzed. None of these factors...
in PSA level within 12 months, but without CaP, and matched this high-risk group to a noncancer, non-PSA-elevated control population to explore background prevalence, incidence, and medication use rates as a framework for better understanding patients in one of our major on-going clinical ...