To confirm the feasibility of sequence-to-drug concept, we compared TransformerCPI2.0 with conventional structure-based drug design approaches to test its ability to screen active molecules from compound libraries. We used the benchmark dataset DUD-E set30 and DEKOIS2.0 set31 and the enrichment fac...
We tested whether the chaperones associated with CRAG might be involved in its degradation. CRAG breakdown was accelerated 2-3-fold in strains with high levels of heat-shock proteins (hsps), i.e. in those that overproduce the hsp transcription factor (sigma 32) or carry a dnaK deletion. A...
To alleviate the ‘black box’ problem and gain insights into the model and its predictions, the field of explainable artificial intelligence (XAI) has been established. In fact, a multitude of XAI methods have been developed that are able to provide explanations of a model’s decision while a...
While such processes may similarly be employed to enhance the impact of public health initiatives, optimisation has not been defined in the context of public health and there has been little exploration of its key concepts. Methods We used a modified, three-round Delphi study with an ...
By measuring response-related muscle activity, electromyography can provide strong evidence for response tendencies and response conflict, but it comes with its drawbacks. It requires specialized equipment, trained personnel to place the electrodes correctly, and often requires adaptations of well-...
Increasing virulence of the coronaviruses in the last two decades is a wake-up call for global health to not only gain in-depth information on virulence factors of its pathogenicity but also provide therapeutic intervention for this severe respiratory illness to end up this dramatic story [8,9...
After the completion of its function, the plate is entirely resorbed and excreted from the body; thus, the need for the plate removal is eliminated. Moreover, in pediatric applications, bioresorbable bone fixation less hinder the natural growth of the skeleton than their biostable counterparts [...
HPTLC may be a useful tool for lipidomics owing to its ease of use, reasonable speed of analysis, and the high number of samples processed per plate. HPTLC can be a complementary tool for LC-based techniques, particularly for routine clinical analyses. ...
We’re going to be able to say many things about the ruliad without engaging in all its technical details. (And—it should be said at the outset—we’re still only at the very beginning of nailing down those technical details and setting up the difficult mathematics and formalism they invo...
not to seek market demand for the concept or choose the best way to produce it. Rather than focusing on building or developing the idea, it tests whether the idea is feasible and viable. In addition, it enables those involved in the proof-of-concept exercise to explore its financial ...