Boman, H.G., 1998, Gene-encoded peptide antibiotics and the concept of innate immunity: An update review. Scandinavian Journal of Immunology 48, 15-25.Boman H. Gene-encoded peptide antibiotics and the concept of innate immunity. An update review. Scand J Immunol 1998;45....
The inability of innate immunity to build an immunological memory is considered a main difference with adaptive immunity. This concept has been challenged by studies in plants, invertebrates and mammals. Recently, a paradigm shift in our understanding host defence has been triggered by the mounting ...
Trained immunity was originally proposed as a program of innate immunity memory by innate immunity cells of hematopoietic origin such as the monocytes/macrophages and the NK cells. Here I discuss some old and new data justifying this program and some specific, still unanswered, questions it raises...
Role of innate immunity in initiation and progression of osteoarthritis, with emphasis on horses 2021, Animals Neutrophil: A cell with many roles in inflammation or several cell types? 2018, Frontiers in Physiology S100-alarmins: potential therapeutic targets for arthritis 2017, Expert Opinion on The...
Figure 3 Osteoimmunomodulatory properties of bone substitute biomaterials 图3 材料的骨免疫调控作用骨替代材料作为异体植入体内后,其物理化学性能如表面形态、孔隙及颗粒大小、活性生物离子的释放等均可对机体的免疫反应产生影响。通过改变材料的理化性能,调控免疫细胞及其生成的骨免疫微环境,影响间充质干细胞的成骨分化...
An immunomodulator can be defined as a substance, which can influence any constituent or function of the immune system in a specific or nonspecific manner including both innate or adaptive arms of the immune response. The Ayurvedic system of medicine details the concept of immunomodulation by the ...
A maternal vaccine to protect neonates against Group B Streptococcus invasive infection is an unmet medical need. Such a vaccine should ideally be offered during the third trimester of pregnancy and induce strong immune responses after a single dose to m
Drug hypersensitivity generated according to the p-i concept is not caused by a newly generated immune response to the drug but is the consequence of cross-reactivity. It does not require the involvement of the innate immune system to trigger immunity. Animal experiments aimed to prove or ...
However, in a rodent model of type 1 diabetes, Bacillus Calmette-Guerin (BCG) reverses disease by restoring insulin secretion. Specifically, it stimulates innate immunity by inducing the host to produce tumor necrosis factor (TNF), which, in turn, kills disease-causing autoimmune cells and ...
Generally, these signals support the establishment of an inflammatory response that recruits innate immune effector cells to sites of cellular stress, but per se fail to elicit antigen-specific adaptive immunity [10]. Such an immune engagement, however, serves as a platform for the potential ...