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Iketani, S., Forouhar, F., Liu, H.et al.Lead compounds for the development of SARS-CoV-2 3CL protease inhibitors.Nat Commun12, 2016 (2021). https://doi.org/10.1038/s41467-021-22362-2 Download citation Received07 July 2020 Accepted10 March 2021 ...
Objective To review the research under the guidance of the OSMAC approach.Methods The OSMAC approach was summarized based on the literatures.Results The OSMAC approach had been successfully applied and the research of the microbial metabolites had made significant progress.Conclusions This review can ...
Lead alkyl compounds are made using a lead anode and an electrolyte containing a Grignard reagent, e.g. EtMgCl, alkyl chloride, and an ether of higher boiling point than the lead alkyl, e.g. the dibutyl or hexyl ethyl ether of diethylene glycol. The electrolytic product is treated with HC...
Nowadays, the reduction in the discovery of new leads and the considerable decline in new drug approvals are fostering a renewed interest in natural products as a source of chemical diversity and lead compounds [10]. Remarkably, the 2015 Nobel Prize in Physiology or Medicine was awarded to thre...
In most instances the reaction will lead to the formation of mixtures of enantiomers (that is when the alkenes are prochiral, or when the faces are enantiotopic). Three important reactions should be mentioned in this context the: 1. Katsuki-Sharpless epoxidation of allylic alcohols 2. Sharpless...
Based on the home-made multiphysics field coupling device,investigation was carried on the fracture behavior and the growth of intermetallic compounds( IMC) at the interface between Sn-3. 0Ag-0. 5Cu lead-free solder and Cu substrate. The results show that in the multiphysics field and 30-150...
sample handling, data collection and processing of the high-throughput structure determination facility, XChem at the Diamond Light Source, UK synchrotron, can be used to screen such CRMs containing compounds that explore how to grow from one vector of a fragment hit to a more potent lead ...
While fields like Artificial Life have made huge strides in quantifying the mechanisms that distinguish living systems from non-living ones, particular mec... AM Adams,E Jacopin,P Gagrani,... - IEEE 被引量: 0发表: 2024年 On the design of lead-like DNA-encoded chemical libraries DNA-encode...
electrochemical approach: a radical generated from single-electron oxidation of a nucleophile on anode could be captured by diazo compound to form a carbon radical intermediate. The fast second single-electron oxidation of the intermediate suppressed the decomposition of the radical, and further was ...