Compound-Target-Pathway Network Analysis and Effective Mechanisms Prediction of Bu-Shen-Jian-Pi Formula Bu-Shen-Jian-Pi formulacompounds-targets-disease networkLiu-Wei-Di-Huang decoctionmolecular mechanismSi-Jun-Zi decoctionObjective: The aim of this study was to predict the active compounds, therapy ...
To collect small molecule drugs and their drug target data such as enzymes,ion channels,G-protein-coupled receptors and nuclear receptors from KEGG database as the training sets,in order to establish drug-target interaction models based on the random forest algorithm. The accuracies of the models...
Computational analysis revealed that TNF-α might be critical target of GAC1 in relieving neutrophil-predominant airway inflammation The compound-target-disease network in Figure 6 shows that 8 targets including TNF, AKT1, STAT6, HDAC2, IL17A, IFNG, NOS2 and NR3C1 are closely associated with GAC...
In order to clarify the pathogenesis of AD and elucidate the mechanism of action ofA. oxyphylla, the compound-target interaction (CT), compound-target-pathway (CTP), and compound-target-pathway-disease (CTPD) network were constructed and analyzed using topological parameters and the subnetwork of ...
Network analysis is based on a “drug-composition-target-disease” relationship characterized by comprehensive analysis, and has been introduced to evaluate the constituents and action mechanism of TCM in view of its systematic and holistic coincidences [7,8,9]. CTGO comprises Turkish gall and ...
to establish and analyze compound-target-disease & function-pathway network so as to find the possible mechanism linking to the role of QSYQ in CI/RI... Y Wang,G Xiao,S He,... - Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 被引量: 0发表: 2020年 Elucidation of the Mech...
Finally, in line with the previously obtained target-associated disease information, a T-cD network were built by linking target proteins together with their relevant diseases. Visualization of all networks were implemented by Cytoscape 2.8.163 and the quantitative property “degree” of these networks...
With most disorders resulting from different causes with each patient, it is likely that tailor-made treatments are necessary to successfully target these diseases. Using iPSC technology, our method enables culture of 96 parallel neuronal-glial networks of one specific patient and allows testing of ...
Unlike TCMID and TCMSP, HERB, published in 2020, used gene targets guided by high-throughput transcriptomic screening experiments to identify herb-disease networks and compound-target networks. INPUT collects multiple resources and embeds a series of tools for network pharmacology analysis. LTM-TCM, ...
Moreover, we found that 6-OAP/CM inhibited the entry of SARS-CoV-2 S protein pseudovirus into target cells. These results suggest that 6-OAP/CM are ACE2 inhibitors that may potentially protect lung epithelial cells from SARS-CoV-2 infection. This is a preview of subscription content, ...