Data are presented as mean ± standard deviation (SD), which were calculated by Graphpad Prism 7 (San Diego, CA). Statistical differences were determined by one-way ANOVA (for more than two groups) with Tukey’s multiple comparison as a post hoc test. P values ≤ 0.05 were considered sign...
The docking tool Discovery Studio 3.0 (Accelrys/Biovia, San Diego, CA, USA) was used to calculate and edit the docking conformation between macrophage migration inhibitory factor (MIF) and MCDC. The standard default settings were used in the calculations, but the minimum site size was set to 5...
Department of Microbial Chemistry, College of Pharmacy, Kyung Hee University, Seoul, Korea D H Kim Department of Biochemistry, College of Oriental Medicine and Research Institute of Oriental Medicine, Dongeui University, Pusan, Korea Y H Choi Department of Chemistry, Research Institute for Natural Sc...
Development and Therapy 23 November 2015 Number of times this article has been viewed Somayeh Fani1 Behnam Kamalidehghan1 Kong Mun Lo2 Najihah Mohd Hashim1 Kit May Chow2 Fatemeh Ahmadipour1 1Department of Pharmacy, Faculty of Medicine, 2Department of Chemistry, Faculty of Science, University of...
Multiscreen filtration plates (96 wells; Millipore, France) were coated with 4 μg/ml of rat anti-mouse gamma interferon (IFN-γ) antibody (clone R4-6A2; PharMingen, San Diego, Calif.), overnight at room temperature. Spleen cells from immunized mice were added to the wells and incubated...
Data were analyzed by using PRISM (version 3; GraphPad, San Diego, CA) and EXCEL (XP 2002; Microsoft, Redmond, WA) software. Body iron stores (BFe) were calculated from the ratio of TfR to SF (TfR:SF) (16). The amount of 57Fe and 58Fe label present in the blood was calculated ...
5University of Groningen, Department of Clinical Pharmacy and Pharmacology, Groningen, the Netherlands. 6Palm Beach Atlantic University, Lloyd L. Gregory School of Pharmacy, Department of Pharmaceutical Sciences, West Palm Beach, FL, USA. 7Department of Physiology and Pathophysiology, University of ...
Primary human hepatocytes (PHHs) (#5200) were obtained from ScienCell Research Laboratories (San Diego, CA) and cultured according to the manufacturer's instructions31. Antibodies. Anti-CD81 monoclonal antibody (mAb) 5A6 from Santa Cruz Biotechnology (Paso Robles, CA), anti-SRB1, anti-...
{, A Purohit1,6 and P A Foster*,1,5,6 1Oncology Drug Discovery Group, Section of Investigative Medicine, Hammersmith Hospital, Imperial College London, London W12 0NN, UK; 2Cancer Institute, UCL, 72 Huntley Street, London WC1E 6BT, UK; 3Medicinal Chemistry, Department of Pharmacy and ...
All statistical tests were conducted using Prism software version 5.0 (GraphPad, San Diego, CA, USA). References 1. Garcia-Carbonero, R., Carnero, A. & Paz-Ares, L. Inhibition of HSP90 molecular chaperones: moving into the clinic. Lancet Oncol. 14, e358–69 (2013). 2. Powers, M. ...