Fig. 2. Selected compound dose-response curves from BacMam-enabled LanthaScreen® cellular assays performed in various cell types. (A) The p110β-selective inhibitor TGX-221 is inactive in cell lines with normal PTEN status, such as BT474 (IC50 >10 µM), but does inhibit PRAS40 phosph...
Figure3depicts the year-to-year time-series and whole-period average maps of the short-term unclean air exposure time (orange bars and maps) and the percentage of population living in short-term clear air areas (blue curves). Here, the annual unclean air exposure time represents the PW aver...
Calibration curves in the 125–1000 mg·L−1 range with good linearity for a four point plot were used to determine the bioactive compound concentration in goji fruit samples; the linearity for each compound was established by plotting the peak area (y) versus the concentration (x) of ...
(e) the calibration curves of formaldehyde, acetaldehyde and pyruvate carbonyl compounds are drawn; (f) the derivative reaction is carried out and analysis is conducted to a sample to be determined; and (g) the technical scheme in which the carbonyl compound in the sample is qualitatively and...
These results did not match with commonly observed breakthrough curves in which the mass transfer zone (MTZ) or primary sorption zone (PSZ) is relatively nar- row, presumably as a consequence of the size of the resin beads [25]. The bead size of XAD16N (20–60 mesh) puts severe ...
Cisplatin is the first and most widely used platinum-based chemotherapy drug and is the cornerstone agent in treating a broad spectrum of cancers. However, its clinical application is often limited by severe toxic side effects and drug resistance. Based
time curves for maturation of a standard polyester using different methods Sign in to download full-size image Figure 8. Effect of temperature on the viscosity of SMC compositions matured using magnesium oxide and a mixed (diphenylmethane diisocyanate (MDI)/magnesium oxide) system ...
while TCDD exposure usually does not. These discrepancies cannot be explained by different windows of sensitivity for effects of 5α-reductase inhibition nor can they be explained by different dose-response curves for effects of 5α-reductase inhibition so it is unlikely that TCDD-induced inhibition...
FIG. 6 shows fluence-response curves for inactivation of β-AGA activity in V79 cells exposed to 1 μg/ml TPCS2afor 18 hours followed by 1 hour incubation in sensitizer-free medium before exposure to red light. FIG. 7 shows dose-response curves for V79 cells incubated with TPPS2aand TP...
The process mainly involves modeling the molecular structure and interactions as a graph, calculating Ollivier-ricci curves on the graph to obtain geometric descriptors, and finally combining them with the gradient boosting tree (GBT) algorithm for prediction of binding affinity. Overall, these ...