Long-term exposure to testosterone is thought to promote BP elevation; it may compromise renal function and impair vascular reactivity.45 Multiple abnormalities, including sympathoactivation, have been implicated in these effects. Testosterone enhances vasoconstriction in response to adrenergic agonists.46 ...
Cannabis is the most widely used drug in the world. It is also the commonest recreational drug consumed by pregnant women. In western countries, up to 20% of pregnant women are exposed to cannabis during pregnancy [1]. In the USA, while fetal exposure to tobacco decreases, cannabis use du...
Renal function was assessed and analyzed with serum cystatin C concentrations; estimated glomerular filtration rate; risk, injury, failure, loss, and end-stage renal disease criteria; and neutrophil gelatinase-associated lipocalin [3C]. Blood transfusion [SEDA-15, 529; SEDA-37, 404; SEDA-38, 336...
Genomic SEM12was used to conduct a multivariate GWAS to analyze the association between SNPs and MetS (Fig.1cand Supplementary Fig.3). Theneffof the MetS factor was estimated to be 1,384,348 and the SNP-based heritability (h2) was estimated to be 0.11. We identified 1,650 lead SNPs fo...
Influence of gender, age and renal function on plasma adiponectin level: the Tanno and Sobetsu study. Eur J Endocrinol 2005; 153: 91–98. 17 Akishita M, Hashimoto M, Ohike Y, Ogawa S, Iijima K, Eto M, Ouchi Y. Low testosterone level is an independent determinant of endothelial ...
The presence of G4s is often linked to a more favorable local chromatin environment for the activation and execu- tion of regulatory function of cCREs, potentially attributable to the formation of G4 secondary structures. Finally, we discovered that G4-associated cC...
Exclusion criteria consisted of unstable coronary syndromes, congestive heart failure greater than New York Heart Association class III, renal failure, acute myocardial infarction in the preceding 3 months, atrial fibrillation or a predominantly paced rhythm, prior TM, or current stress management ...
Sorafenib was approved as the first-line drug for advanced hepatocellular carcinoma (HCC) and was also used in the treatment of advanced clear-cell renal-cell carcinoma and radioactive iodine-refractory, locally advanced or metastatic differentiated thyroid cancer [1], [2], [3]. In recent years...
Renal functionGENERAL JAPANESE POPULATIONINSULIN-RESISTANCEMAGNESIUM INTAKEDIETARY MAGNESIUMDISEASERISKBackground Metabolic syndrome (MetS) is presented with a cluster of cardio-metabolic risk factors with widespread prevalence. In the present case-control study, we aimed to examine the relationship between ...
The expression levels of IL6 are high in most inflammatory processes, and are upregulated in many types of cancers including multiple myeloma, lymphoma, ovarian cancer, prostate cancer, renal cancer and carcinoma of the skin.31 Interestingly, the expression levels of IL6 is also directly linked ...