Components of Neurons A neuron is a nerve cell. It receives signals via chemicals called neurotransmitters. It then transmits the signals, electrically. A neuron consists of a cell body or soma, dendrites, and a
Neocortical development depends on the intrinsic ability of neural stem and progenitor cells to proliferate and differentiate to generate the different kinds of neurons in the adult brain. These progenitor cells can be distinguished into apical progenitors, which occupy a stem...
The connection between dementia and the pathological protein inclusions that signify AD was first reported by Alois Alzheimer in 1906 [9] and the senile plaques were defined as amyloid by the observation of Congo red binding [10]. However, it would take almost 80 years from the first report b...
(3). EVs are thought to serve various functions depending on their origin and molecular composition: exosomes generated by invagination of endosomal membranes and by subsequent release of multivesicular bodies (MVBs) may transfer signaling molecules, such as miRNA, transcripts, proteins, and lipids, ...
2. The MAPK signaling cascades and their functions 3. Nuclear functions of the ERK1/2 cascade 4. Nuclear functions of the other MAPK cascades 5. Mechanisms of ERK5 and ERK1/2 translocation into the nucleus 6. Summary Acknowledgements ReferencesShow full outline Cited by (786) Figures (2)Bi...
et al. Long-range inhibitory intersection of a retrosplenial thalamocortical circuit by apical tuft-targeting CA1 neurons. Nat. Neurosci. 22, 618–626 (2019). Article CAS PubMed PubMed Central Google Scholar Taube, J. S. The head direction signal: origins and sensory-motor integration. Annu...
One hypothalamic neural population, which are essential for controlling stress responses, are the corticotropin-releasing hormone (CRH) neurons located in the paraventricular nucleus (PVN). In addition to their well-known role in controlling corticosteroid (CORT) secretion, this neural population has ...
(1997). A subset of olfactory neurons that selectively express cGMP-stimulated phosphodiesterase (PDE2) and guanylyl cyclase-D define a unique olfactory signal transduction pathway. Proc. Natl. Acad. Sci. U.S.A. 94, 3388–3395.10.1073/pnas.94.7.3388Search in Google Scholar Kalderon, D. and...
This paper provide a comprehensive overview of extracellular proteins that have been shown to interact with Aβ and a discussion of their potential roles in AD pathology. Methods that can expand the knowledge about how the proteins are incorporated in plaques are described. Top-down methods to ...
The co-occurrence of unhealthy metabolic traits has prompted ongoing endeavors to unveil their common genetic underpinnings. For instance, five categories of T2D mechanistic pathways were identified using T2D-associated variants through clustering analyses, and the genes and traits associated with each clus...