LIPID COMPONENTS OF HUMAN MYELIN MEMBRANES FORMING THE MYELIN SHEATHHartmut PilzBiochemical Factors Concerned in the Functional Activity of the Nervous System
The majority of the data available on the immunology of central nervous system (CNS) myelin relate to the specificity of myelin, and in particular its basic protein component, in bringing about the clinical signs and histopathologically defined lesions characteristic of experimental allergic encephalomyel...
nerve crush or cut. The findings suggest that, in the distal segment of crushed nerve, the lipid content as well as the myelin lipid synthesis increase as the regeneration period proceeds. 展开 关键词: Animals Rats, Inbred Strains Rats Sciatic Nerve Myelin Sheath 2',3'-Cyclic-Nucleotide ...
Also, heme can be released from oxidized hemoglobin and, being a hydrophobic molecule, can readily enter the hydrophobic domains of biological membranes [34]. Thus, free heme can enter the myelin sheath and cause oxidative damage directly to the constituent lipids and proteins [35]. Those ...
-Phospholipids(0.5) are basic components of membrane (0.5), contribute to differential permeability of the membrane (0.5) and help to maintain membrane / cell / organelle integrity (0.5) -High lipid content inmyelin sheath of nerve fibre(0.5) insulates against cross-talks (0.5) and facilitates...
A) Distributions of optic nerve damage at 12 mo. B) Representative images from nerves with no glaucoma have a clear axoplasm and darkly stained myelin sheath. Nerves with severe damage have extensive axon loss and glial scarring. CD94 status did not alter glaucomatous optic nerve damage. For ...
Oligodendrocytes:These are myelinating cells in the central nervous system. They surround the axons of neurons with a fatty, myelin sheath that insulates the electrical signal and allows for quicker communication. Ependymal cells:These are cells which line part of the brain called ventricles, which...
N. 1972. Biosynthesis of the myelin sheath. Lipids, malnutrition and the developing brain. Ciba Found. Symp. 73-90. 9. DETTERING,N. K., and M. A. WELLS. 1976. The non-synchronous synthesis of myelin components during the early stages of myelination in the rat optic nerve. J. ...
Myelin SheathAnimalsRats, Inbred StrainsHumansRatsPhenylketonuriasAmino Acid Metabolism, Inborn ErrorsDisease Models, AnimalLysinePhenylalanineThe turnover of myelin and of myelin protein fractions has been measured in the central nervous system of rats who were placed on a hyperphenylalaninaemia-inducing...
Such recovery is often prevented by the release of chemicals and proteins such as Nogo-A which is a myelin-associated neurite outgrowth inhibitor which inhibits axonal regeneration via a specific receptor (Chen et al., 2000). Unfortunately there is no current treatment for NAION. 4. Existing ...