Injection of marijuana components into mice or rats often results in a suppression of antibody-forming capacity and the capacity to develop delayed hypersensitivity responses, and to resist challenge by a lethal
Materials and methods The median lethal dose (LD50) was evaluated through acute toxicity test. The pharmacokinetics of five components after oral administration of extracts of RPT, LPT, HPT (all equivalent to 1.9 g/kg of RPT extract for one dose) and 0.5% CMC-Na solution (control group) ...
Rechargeable LiBs are a critical component of sustainable energy infrastructure13,14, and demand for use in electric cars and electronics (e.g., cell phones, medical devices, smart watches, laptops) is anticipated to grow exponentially over the next decade15. Up to 96% of bis-FMeSI is recove...
2, substantial epigenomic alterations underlie many aspects of tumorigenesis and cancer susceptibility3,4,5,6, suggesting that genetic mechanisms might not be the only drivers of malignant transformation7. However, whether purely non-genetic mechanisms are sufficient to initiate tumorigenesis...
Unlike endoparasitoids whose venom can induce various effects ranging from the regulation/alteration of host p hysiology13,14 to transiently paralyzing even lethal effects15,16, ectoparasitoid venom paralyze or rapidly kill the host12,17. To better understand the pathological syndrome ...
Resistance of pathogens to antimicrobial compounds has lethal effects as the development of drug resistance outpaces the development of new drugs. Infectious diseases, a leading cause of untimely death worldwide, have become a global concern. The clinical effectiveness of many existing antibiotics is ...
Peripheral Inflammation Results in Specific Alterations in Cholinergic System Component Gene Expression Next, we examined the impact of lethal inflammation on the expression of major genes associated with the brain cholinergic system. The gene expression of choline acetyltransferase (ChAT) (the enzyme ...
3.1. The combination of phillyrin, emodin, baicalin, and liquiritin significantly increases the survival of zebrafish infected by lethal LPS Firstly, the toxicity of phillyrin, emodin, baicalin, and liquiritin in zebrafish larvae were examined within 72 h. And the nontoxic concentration of phillyrin...
of dsRNA (Fig.1). There are currently no honey bee virus isolates or infectious clones, so we utilized a recombinant Sindbis virus that expresses GFP (SINV-GFP) as a tractable model of virus infection in honey bees22. SINV-GFP inoculations were performed via intrathoracic injection in the ...
The PA forms oligomers, hepta- or octamers when cleaved by furin protease, and forms a pore in cellular membranes for delivery of 2 other toxins: metalloprotease Edema Factor (EF) [35,36] and adenylate cyclase Lethal Factor (LF) [37]. 2.2.2. Vaccines There are 2 vaccines available ...