We demonstrate the presence in the human fetal testis of two key endocannabinoids, 2-arachidonylglycerol (2-AG) and to a lower level anandamide (AEA), as well as a range of enzymes and receptors for the ECS. Ex vivo exposure of first trimester testes to CBD, THC, or CBD/THC [ratio 1...
Human health is a culmination of dynamic interactions and regulations by several genetic, non-genetic, and environmental factors. The regulatory systems of the body work intricately and coordinately to maintain functional homeostasis in cells and tissues by sensing and regulating nutrient availability and ...
Eventually this can arrest the parasite life cycle in the ticks, leading to the suppression of transo- varial transmission and potentially to the eradication of the disease [10, 11]. However, a control approach based solely on TBVs might not be fully effective in areas where cattle co-exist...
The genetic compensation response (GCR) has recently been proposed as a possible explanation for the phenotypic discrepancies between gene-knockout and gene-knockdown1,2; however, the underlying molecular mechanism of the GCR remains uncharacterized. Here, using zebrafish knockdown and knockout models ...
In this paper, the application of 3D fracture mechanics analysis on a gas turbine blade for predicting crack arrest is presented. A comparison of stress intensity factor values from 3D and 2D analysis is also shown. The 3D crack growth analysis was performed by using FRANC3D in conjunction ...
Another study showed that polyphenols from aqueous extracts of cocoa have showed remarkable potential in the protection of NB cells against oxidative stress [66]. While further research is needed, it is reasonable to assume that antioxidants can have beneficial effects for cancer therapy, particularly...
Based on the highly homologous primary structures of the large scorpaenoid toxins, it is reasonable to surmise that they also share a mechanism of action. This is supported by the fact that SNTX, trachynilysin, and Sp-CTx have all been shown to work by forming pores in cell membranes. ...
Thus, it was reasonable to assume that in the capsDATS-treated group, the levels of sulfurtransferase activity and/or expression level of their genes would be altered that was expected. According to data collected in Table 3, the activity of TST and CTH increased as compared with the control...