The influence of different combinations on the anticancer effect of CPT-11 was first evaluated in vitro by cell viability, wound healing ability, cloning formation, apoptosis, and cell cycle arrest. Then, a CRC xenograft mice model was constructed to evaluate the anticancer effect of the optimal ...
An artificial foot and ankle joint consists of a curved leaf spring foot member having a heel extremity and a toe extremity, and a flexible elastic ankle member that connects the foot member for rotat
The genetic compensation response (GCR) has recently been proposed as a possible explanation for the phenotypic discrepancies between gene-knockout and gene-knockdown1,2; however, the underlying molecular mechanism of the GCR remains uncharacterized. Here, using zebrafish knockdown and knockout models ...
Human health is a culmination of dynamic interactions and regulations by several genetic, non-genetic, and environmental factors. The regulatory systems of the body work intricately and coordinately to maintain functional homeostasis in cells and tissues by sensing and regulating nutrient availability and ...
Diminished ovarian reserve (DOR) refers to a decrease in the number and quality of oocytes in the ovary, which results in a lack of sex hormones and a decline of fertility in women. DOR can potentially progress to premature ovarian failure (POF), which h
Historical hunting pressures on koalas in the southern part of their range in Australia have led to a marked genetic bottleneck when compared with their no
The need for informed consent was waived owing to the retrospective nature of the study. Data Availability Statement The datasets used and analyzed during the current study are available from the corresponding author on reasonable request. Acknowledgments We appreciate the statistical support provided by...
Cancer stem cells (CSCs) refer to a certain subpopulation within the tumor entity that is characterized by restricted cellular proliferation and multipotent differentiation potency. The existence of CSCs has been proven to contribute to the heterogeneity of malignancies, accounting for intensified tumorigene...
Based on the highly homologous primary structures of the large scorpaenoid toxins, it is reasonable to surmise that they also share a mechanism of action. This is supported by the fact that SNTX, trachynilysin, and Sp-CTx have all been shown to work by forming pores in cell membranes. ...
Based on the highly homologous primary structures of the large scorpaenoid toxins, it is reasonable to surmise that they also share a mechanism of action. This is supported by the fact that SNTX, trachynilysin, and Sp-CTx have all been shown to work by forming pores in cell membranes. ...