Together they represent a novel bioinformatics-based toolbox for analyses of genetic variation in human traits and disease. e esis is structured as follows. Chapter presents a few introductory remarks to integrative systems biology, and Chapter gives a brief description of human genetic variation and...
However, these findings also open up many more questions for future study by investigators with diverse interests and skills. Temperament researchers have varied in whether they focused on individual traits or subtypes defined by profiles of multiple traits. We found that most of the genes for each...
gene regulatory networks, and genomic evolution. However, their functional role in pigs and contributions to complex traits are largely unknown. We created a catalog of TEs (n = 3,087,929) in pigs and found that young SINEs were predominantly silenced by histone...
This book presents selected contributions to the 19th Evolutionary Biology Meeting, which took place in September 2015 in Marseille. It consists of 22 chapters, which are grouped in four sections: · Convergent Evolution · Evolution of Complex Traits · Concepts · Methods The annual Evolutionary Bi...
Simultaneously, cross-disease investigations have uncovered significant overlap in the phenotypic traits associated with the genetic risk shared by ADHD, ASD, and TS [1]. Grounded in the characteristic features of inattention, hyperactivity, and impulsivity commonly observed in individuals with ADHD, prev...
some form of adaptation is required. Within defence science, the adaptability of individuals, groups and enterprises can be improved. Engineered systems can move beyond mimicking biological traits to incorporating genuinely adaptive mechanisms that allow for novel patterns of behaviour to emerge in respons...
she further resents her mother. When the girl begins to identify with the mother and take on certain behaviors and personality traits, Freud would argue that she has “resolved” her phallic phase of psychosexual development. However, Freud also believed that if a girl failed to resolve this ...
Traits have been exhaustively mapped and decomposed in haploid models10,11,12,32,33but extrapolation from haploid screens to the biology of diploids is precarious. Haploid designs cannot be used to measure intralocus interactions in the form of dominance, further, they only capture additive-by-add...
Multiplex analysis provides an inter-tissue framework for the analysis of high-dimensional molecular traits, such as gene expression. The global multiplexity matrix was obtained for each of the five proposed architectures. We extracted from the global multiplexity matrices the groups of genes with the...
KAML: improving genomic prediction accuracy of complex traits using machine learning determined parameters Lilin Yin, Haohao Zhang, Xiang Zhou, Xiaohui Yuan, Shuhong Zhao, Xinyun Li & Xiaolei Liu Genome Biology volume 21, Article number: 146 (2020) Cite this article 15k Accesses 48 Citations ...