5e)41. Because the domain-swapped architecture is the well-accepted architecture of the TRP channel superfamily42, our TRPV4-RhoA structures represent physiologically relevant conformations. Agonist- and antagonist-dependent TRPV4 gating In our ligand-bound 3D cryo-EM reconstructions, we identified ...
This paper reports data from a study that seeks to characterize the differences in design structure between complex software products. We use Design Structure Matrices (DSMs) to map dependencies between the elements of a design and define metrics that allow us to compare the structures of different...
In this paper we present a different perspective on the human visual system that suggests a rather different approach to vision research that places a greater emphasis on structures that can learn representations than on designing the representations. We present results of an architecture for ...
Views are chosen to represent stakeholder concerns and used to document software structures (elements, relations, and properties of each) including interfaces and behavior. Beyond the set of documented views, architects add information to describe the overall architecture rationale and approach, and to ...
(inset)), reminiscent of cell bridges observed in other archaea37,38,39,40. Although the majority of cells exceeded the thickness limitation of cryo-ET, some were thin enough to visualize the internal architecture (Fig.4c) in 3D, enabling us to not only observe large protein structures such...
8 Data Structures That Power Your Databases The answer will vary depending on your use case. Data can be indexed in memory or on disk. Similarly, data formats vary, such as numbers, strings, geographic coordinates, etc. The system might be write-heavy or read-heavy. All of these factors ...
The unusual and complex structures of the breakdown time-delay distributions in a neon-filled diode at 4 mbar pressure for lower overvoltages are reported in this paper. Each distribution was established on the basis of the 1000 successive and independent measurements of the electrical breakdown time...
Community structures are an important property of complex networks. For example, tightly connected groups of nodes in a social network represent individuals belonging to social communities, tightly connected groups of nodes in the World Wide Web often correspond to pages on common topics, while communi...
the complex network functionality is of high relevance for supply, transportation, and epidemic spreading networks. The authors propose a metric to evaluate nodal dominance based on competition dynamics that integrate local and global topological information, revealing fragile structures in complex networks....
These two structures are aligned based on PsrB, the domain containing four iron–sulfur clusters. Extended Data Fig. 6 The proposed quinone pocket in ActC. a, Sequence alignment of the ActC from F. johnsoniae, R. marinus, and Chloroflexus aurantiacus. The transmembrane α-helices are labelled...