Only a minority of patients achieve complete molecular response (CMR), as defined by undetectable levels of BCR-ABL fusion transcripts by PCR with sensitivity of at least 4.5 logs. Achieving CMR may offer the possibility of treatment discontinuation. Aims: To identify patients with sustained CMR (...
2. Case Presentation We report two cases of CML patients carrying the p230 transcript, who achieved fast and deep complete molecular response (CMR), defined as the absence of detectable BCR-ABL transcripts by RQ-PCR, after frontline treatment with nilotinib. The first patient was a 40-year-...
have been completely sequenced, while other strains have been partially sequenced or are currently under way http://genome.microbio.uab.edu/strep/info/; http://www.sanger.ac.uk/Projects/S_pneumoniae/;http://cmr.tigr.org; http://www.genomesonline.orghttp://www.ncbi.nlm.nih.gov/genome/. ...
The human brain remains a great mystery in science and current researchers strive to understand molecular and cellular processes of the nervous system. Prevention and effective treatment of neurological disorders has been a major medical challenge. Vimentin PAb(Cat. No.:E-AB-33218) Vimentin, also ...
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Ultrasensitive response motifs: basic amplifier in molecular signalling networks. Open, Biol. 3, 130031 (2013). 19. Thattai, M. & van Oudenaarden, A. Attenuation of noise in ultrasensitive signaling cascades, Biophys. J. 82, 2943 (2002). 20. Bradshaw M., Kubota, Y., Meyer T. & ...
Pereira PS, de Araujo CFM, Seki LM, Zahner V, Carvalho-Assef APD, Asensi MD: Update of the molecular epidemiology of KPC-2-producing Klebsiella pneumoniae in Brazil: spread of clonal complex 11 (ST11, ST437 and ST340). J Antimicrob Chemother. 2013, 68: 312-316. 10.1093/jac/dks396....
Klebsiella pneumoniae is an important opportunistic pathogen associated with nosocomial and community-acquired infections. A wide repertoire of virulence and antimicrobial resistance genes is present in K. pneumoniae genomes, which can constitute extra c
Complete molecular response (CMR) was defined as undetectable BCR-ABL at a PCR sensitivity of at least 4.5 logs below the standardized baseline value confirmed on subsequent analysis after at least 3 months. The BCR control transcript level determined sensitivity and was dependent on RNA quality ...
The impact of achieving complete molecular response (CMR) in Philadelphia chromosome positive (Ph+) acute lymphoblastic leukemia (ALL) remains undefined. We evaluated the impact of CMR on outcomes among 85 patients with + ALL who received first-line hyperfractionated cyclophosphamide,...