BiochemistryA complex system of proteins found in normal blood serum that combines with antibodies to destroy pathogenic bacteria and other foreign cells.Also calledalexin 【生物化学】(血清中的)补体:在普通血清中由抗体组成的破坏病原细菌与外来细胞的一种复杂的蛋白质系统也作alexin ...
enzyme - any of several complex proteins that are produced by cells and act as catalysts in specific biochemical reactions 6. complement - either of two parts that mutually complete each other counterpart, opposite number, vis-a-vis - a person or thing having the same function or characteristics...
I. et al. Role of C5b-9 complement complex and response gene to complement-32 (RGC-32) in cancer. Immunol. Res. 56, 109–121 (2013). CAS PubMed Google Scholar Towner, L. D., Wheat, R. A., Hughes, T. R. & Morgan, B. P. Complement membrane attack and tumorigenesis: a ...
Although the complement system represents a formidably complex array of interacting proteins, at its centre there lies a single enzymatic reaction, namely the cleavage of C3 into its two primary fragments C3a and C3b. This reaction can be brought about by a number of enzymes but physiologically ...
The complement system was initially viewed as an arm of innate immune defenses against invading pathogens by tagging them for elimination by professional phagocytes or by direct killing through pore formation. The association between hereditary or acquir
The main therapeutic strategies are inhibition of complement activation components, inhibition of complement receptors, and inhibition of membrane attack complex. At present, none of the available agents was proven to be both safe and effective for treatment of autoimmune diseases in humans. Nonetheless...
complement activation occurs at the level of C1 and the MBL–MASP complex by C1-inhibitor (C1-INH), at the amplification level byfactors Iand H, and by various regulators at the levels of C4b2a and MAC formation (Table 1). Next to regulation of complement activation in the fluid phase,...
2006). The C2 and CFB genes are found in close proximity to each other in the major histocompatibility complex (MHC) class III region on chromosome 6, separated by only 500 base pairs. They both code for precursors of C3 convertase. C2 is cleaved to C2b, which combines with C4b to form...
Architecture of the Replication Complex and DNA Loops at the Fork Generated by the Bacteriophage T4 Proteins. of a trombone loop in the T4 system; Visualization of rolling circle replication intermediates generated using the full complement of T4 replication proteins... Chastain,II,Paul,... - 《J...
Pathwaysofcomplementactivation:1.Classicalpathway2.Lectinpathway(MBLpathway)MBL:mannan-bindinglectin3.AlternativepathwayTerminalpathway Classicalpathway asuitableAbboundtoantigen(Ag),Ag-Abcomplex(IC)C1,C4,C2andC3Ca++andMg++cations Activators:ActivationofthispathwaymayoccurviaAg-Abcomplex(immunecomplex,IC).IgG...