REVIEWS Complement, a target for therapy in inflammatory and degenerative diseases B. Paul Morgan1 and Claire L. Harris1,2 Abstract | The complement system is a key innate immune defence against infection and an important driver of inflammation; however, these very properties can also cause ...
ARTICLES Subcapsular encounter and complement-dependent transport of immune complexes by lymph node B cells Tri Giang Phan1, Irina Grigorova1, Takaharu Okada1,2 & Jason G Cyster1 The mechanism of B cell–antigen encounter in lymphoid tissues is incompletely understood. It is also unclear how ...
Factor H (FH) is a natural inhibitor of the alternative pathway (AP) of complement (C) activation, an abundant protein in blood whose reduced level has been associated with proneness for increased C activation. There are also 5 FH-related proteins (FHR), which have different impacts on C ...
The autoactivation steps of MASP-1 were separately quantified using these mutants and the wild type enzyme. Analogous mutants were made for MASP-2, and rate constants of the autoactivation steps as well as the possible cross-activation steps between MASP-1 and MASP-2 were determined. Based on...
of increased cell symmetry. We tested this hypothesis for human PMNs by comparing the whole cell shape or the cells' aggregation state with the light transmission under particular experimental conditions. The PMN light response to the chemoattractant, f-Met-Leu-Phe, in the presence of low doses...
38 infants less than 1 year old, with diarrhoea and electrolytic disorders of 2nd and 3rd degrees and malnutrition on 1st to 3rd degree were studied. The patients were divided into two groups: Group I - 18 infants (11 males, 7 females) who received a conventional feeding program, ...