29kAccesses 176Citations 142Altmetric Metrics Abstract Hyperactivation of the complement and coagulation systems is recognized as part of the clinical syndrome of COVID-19. Here we review systemic complement activation and local complement activation in response to the causative virus severe acute respira...
Formation of immune complexes is a physiological process and an essential part of humoral immunity. Complement plays a major role in the normal processing of these complexes so that they are efficiently and safely disposed of in the reticuloendothelial system. In certain situations, however, immune ...
In this chapter we have summarized the body of evidence that supports a role for the complement system and complement regulatory proteins in the pathogenesis of diabetic complications, with specific...doi:10.1007/978-3-319-21927-1_2Jose A. Halperin...
In July, a comparatively small group of geneticists from 23 countries met, first in Mainz and again in Berlin at the Immunology Congress, to have a closer look at the major histocompatibility complex (MHC) class III genes and other complement polymorphisms. Class III genes include not only comp...
Infection with the Gram-negative pathogen Prevotella intermedia gives rise to periodontitis and a growing number of studies implies an association of P. intermedia with rheumatoid arthritis. The serine protease Factor I (FI) is the central inhibitor of complement degrading complement components C3b and...
Human eosinophils obtained by dextran sedimentation of human blood containing a leukocyte differential with greater than 75% eosinophils have been studied for chemotaxis using the modified Boyden chamber. Eosinophils respond to fresh homologous serum treated with immune complexes or plasmin. Ultracentrifugal...
IC helps reduce the potentially harmful sequelae associated with the presence of immunogenic autoantigen/antibody conglomerates and the subsequent generation of autoantibodies, which may then be deposited on and cause damage to otherwise healthy tissues [24,[26], [27], [28], [29], [30], [31]...
The complement system is a key innate immune defence against infection and an important driver of inflammation; however, these very properties can also cause harm. Inappropriate or uncontrolled activation of complement can cause local and/or systemic inflammation, tissue damage and disease. Complement ...
Complement of forms 来自 Springer 喜欢 0 阅读量: 15 作者:Z Sebestyén,T Titkos 摘要: The notions of the parallel sum, the parallel difference, and the complement of two nonnegative sesquilinear forms were introduced and studied by Hassi, Sebestyé and de Snoo in Hassi et al. (Oper Theory...
At least two explanations can be given for the very great liability to bacterial infection of children with sickle cell anaemia-they suffer from functional asplenia, and their serum fails to opsonize pneumococci. The latter defect implies a failure of complement, but in fact the children show no...