In the aftermath of a trauma, people sometimes hold conflicting ideas in their mind. Trauma, as well as addiction, can lead to a psychic architecture built of walls, closets, and closed doors, so that thoughts or experiences can be kept in different “rooms.” A therapist can help the pat...
occurs when a learner has two different, potentially contradictory schemes in his or her cognitive structure; in a typical case, a student deals with the same mathematical concept in an inconsistent or incoherent way, or activates a less relevant scheme to the situation in his or her mind. Thi...
Although monocarboxylates poorly cross the blood brain barrier (BBB), such substrates could replace glucose if produced locally. The two key enzymatiques systems required for the production of these monocarboxylates are lactate dehydrogenase (LDH; EC1.1.1.27) that catalyses the interconversion of ...
Thus you must estimate your amplitude decay ratio based upon the amplitude spectrum of your entire seismic data cube and your area of interest. Then estimate laterally the spectral amplitude decay ratio between the regions with and without faults. Keep in mind that your amplitude spectrum is ...
At the turn of the twenty-first century, fundamental changes took place in the understanding of the structure and function of proteins and then in the appreciation of the intracellular space organization. A rather mechanistic model of the organization of living matter, where the function of proteins...
Wet-dry cycling on the early Earth is thought to have facilitated production of molecular building blocks of life, but its impact on self-assembly and compartmentalization remains largely unexplored. Here, we investigate dehydration/rehydration of comple
The trafficking behavior of the lipid raft-dwelling US9 protein from Herpes Simplex Virus strikingly overlaps with that of the amyloid precursor protein (APP). Both US9 and APP processing machinery rely on their ability to shuttle between endosomes and plasma membranes, as well as on their latera...
The discovery of intrinsically disordered proteins (IDPs) that do not have an ordered structure and nevertheless perform essential functions has opened a new era in the understanding of cellular compartmentalization. It threw the bridge from the mostly mechanistic model of the organization of the livin...
Keeping the above considerations in mind, we used previously established hiPSC-derived MN culture protocols and a range of techniques to re-visit measurements of metabolic rates in motoneurons. We aimed to (1) increase the sensitivity of our measurements; (2) assess changes in specific cell ...
of Psychiatry, Service of Neuropsychiatry, University Hospitals of Geneva, Belle-Idée, Switzerland, 2 Institute of Physiology, Faculty of Medicine, University of Lausanne, Switzerland, 3 Brain and Mind Institute, Ecole Polytechnique Fédérale de Lausanne, University Medical Centre, University of ...