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suggesting a deviation from neutral expectations (Ka/Ks = 1) and negative Darwinian selection during the evolution of vertebrates (one-tailed z-tests,
Vol 437|1 September 2005|doi:10.1038/nature04072 ARTICLES Initial sequence of the chimpanzee genome and comparison with the human genome The Chimpanzee Sequencing and Analysis Consortium* Here we present a draft genome sequence of the common chimpanzee (Pan troglodytes). Through comparison with the ...
Analyses were performed in R, version 3.6.3 (R Foundation); a P value less than .05 was considered statistically significant, and all tests were 2-sided. Results Table 1 summarizes the characteristics of Black and non-Hispanic White women with breast cancer in the CARRIERS consortium population...
We estimated genomic race using principal component analysis of germline genotype data from 1062 patients (eMethods in Supplement 2). Patients were grouped into genomic black (≥50% African ancestry) or genomic white (≥90% European ancestry). Herein, we present analytical methods unique to this ...
Blouin MS (2003) DNA-based methods for pedigree reconstruction and kinship analysis in natural populations. Trends Ecol Evol 18:503–511 Article Google Scholar Blouin MS, Parsons M, Lacaille V, Lotz S (1996) Use of microsatellite loci to classify individuals by relatedness. Mol Ecol 5:393–...
For the management of such protected areas and conservation breeding purposes, honey bee subspecies have been routinely identified through wing morphology and through DNA-hybrid tests using microsatellite markers. Currently, new methods are evolving including rapid innovations in single-nucleotide polymorphism...
(28%) prior NHGRI Catalog SNP-phenotype associations atP< 0.05 with a consistent direction of effect (Supplementary Fig. 2). The probability of replicating 210 associations out of 751 tests by chance, under the null hypothesis, at the α = 0.05 level is 4 × 10−94. However, when ...
However, different methods vary in coalescent model. The coalescent is a population their ability to detect recombination (Posada, 2002; genetics model that tracks the ancestry of present Stumpf and McVean, 2003; Didelot and Falush, day individuals back in time to their last common 2007), ...
Methods An internal institutional review board (IRB) deemed the retrospective analysis of Optum Labs administrative deidentified claims data exempt from review and patient consent requirement because the study was a secondary analysis of previously collected data. Use of patient data obtained from GGT pe...