Circuit and cell type prioritization for complex disorders is crucial to direct future efforts. Here the authors integrate GWAS, human single-cell RNA-seq and fMRI analysis suggesting multi-modality convergence on amygdalar and hippocampal circuits. Shuyang Yao , Arvid Harder & Jens Hjerling-Leffler ...
Scientists discover how mutations affect calcium release channel and impact muscle disorders The type 1 ryanodine receptor (RyR1) is an important calcium release channel in skeletal muscles essential for muscle contraction. It mediates calcium release from the sarcoplasmic reticulum, a calcium-storing orga...
Hudes maneuvers theatrically with sceneries and scenes within her dramatization of the intersecting and interacting spaces of reality, virtuality, and supernaturality and their influence on character identification and orientation. She uses a technique of splitting and intersecting both the scenes and scene...
Aging is a global challenge, marked in the lungs by function decline and structural disorders, which affects the health of the elderly population. To explore anti-aging strategies, we develop a dynamic atlas covering 45 cell types in human lungs, spanning from embryonic development to aging. We ...
This article examines the mediating role of ethical issues and healthcare on the relationship between the Metaverse and mental health. It also investigates the impact of the Metaverse on ethical issues and healthcare. It is based on quantitative methodol
Fast, thorough peer review: group of editors selected on the basis of their insightful, dedicated and prompt service Rapid publication: publication within 2 months of submission Inclusion in all major indexing services, such as PubMed, MEDLINE and Web of Science Open access: enabling it to be ...
Research in her laboratory uses an interdisciplinary approach at the intersection of developmental psychology, cognitive science, and neuroscience to elucidate how learning, memory, and cognitive control processes interact in childhood, adolescence and in aging, and how motivational factors influence their ...
The hijacking of early developmental programs is a canonical feature of gliomas where neoplastic cells resemble neurodevelopmental lineages and possess mechanisms of stem cell resilience. Given these parallels, uncovering how and when in developmental ti
Due to the ease of access to the diseased tissue, gene therapy may be particularly promising for monogenic skin disorders and researchers have been working on gene therapies for epidermolysis bullosa for over a decade28. As a result, in May 2023, the FDA approved,viaits fast-track process, ...
astrocyte communication may be of high therapeutic potential in neurodegenerative diseases including prion diseases. Several proinflammatory cytokines are upregulated in the brain during the disease course in mouse prion disorders including TNF-α, IL-1α and C1qa [12,29]. However, whether the ...