Becker KG (2004) The common variants/multiple disease hypothesis of common complex genetic disorders. Med Hypotheses 62(2): 309-317.Becker KG. The common variants/multiple disease hypothesis of common complex g
There are thousands of rare human disorders that are caused by single deleterious, protein-coding genetic variants1. However, patients with the same genetic defect can have different clinical presentations2–4, and some individuals who carry known diseas
Liability to alcohol dependence (AD) is heritable, but little is known about its complex polygenic architecture or its genetic relationship with other disorders. To discover loci associated with AD and characterize the relationship between AD and other psychiatric and behavioral outcomes, we carried out...
When a sperm cell with 23 chromosomes and an egg with 23 chromosomes unite, they begin to form a fetus with appropriate genetic makeup. In some cases, however, sperm cells and eggs have extra chromosomes which result in genetic disorders. Down syndrome is one of the most common genetic ...
Genetic disorders are due to the mutation in a gene. About 4,000 diseases of humans have recognised genetic basis. The mutant allele may be recessive or dominant and may be found on autosomal or sex chromosomes. These diseases affect 1-2% of the human population. These can be categorised ...
当当中国进口图书旗舰店在线销售正版《预订 Guide to the Most Common Genetic Disorders - PART THREE: 9783659595899》。最新《预订 Guide to the Most Common Genetic Disorders - PART THREE: 9783659595899》简介、书评、试读、价格、图片等相关信息,尽在DangDang.com
As a result, genetic variants have been identified for psychiatric disorders including ADHD, ASD, schizophrenia, bipolar disorder, and major depressive disorder (MDD).16, 17, 18, 19, 20, 21 Furthermore, there has been rapid development of polygenic techniques22, 23, 24 that investigate the ...
A massive new study finds a high degree of genetic overlap between psychiatric disorders that current clinical diagnostic categories do not accurately reflect.
of IL654. This variant allele is more common in diabetic patients compared to healthy controls55. In addition, this allele increases the risk of obesity-related metabolic disorders, especially insulin resistance, in people with excessive body-weight56. High prevalence of overweight and obesity in ...
Monogenetic disorders resisted early gene therapy, which struggled to achieve long-term expression of genes that were introduced with the intention of replacing or disrupting faulty genes. Also, monogenetic disorders, which affect small patient populations, seemed to offer limited commercial reward. ...