The results demonstrated the up-regulation of SH3RF1 in the cortex, hippocampus and kidney of mice, which was further confirmed by immunofluorescence and Western blot validation. Notably, SH3RF1 is a scaffold protein involved in cell survival in the JNK signaling pathway. Based on these ...
Common fragile sites (CFSs) are large chromosomal regions that exhibit breakage on metaphase chromosomes upon replication stress. They become preferentially unstable at the early stage of cancer development and are hotspots for chromosomal rearrangements in cancers. Increasing evidence has highlighted the co...
The laboratory mouse is the most used species of animals in research, with an estimate of 61% of laboratory animals used in the European Union in 2017 [12]. Therefore, A&A in mice may constitute a major part of the problem with laboratory animal anesthesia. There are at least three inval...
Apart from acting as a molecular 'scaffold' between helix G and the subunit interface, we speculated that translation of helix G with respect to the subunit interface during common gating could alter the geometry of this network. To investigate this possibility we first examined the functional ...
[32]. Our range-wide sampling of reference populations and multiple genetic loci provided the scaffold to infer the most likely geographic source of these samples. It is possible that even more fine-scale sampling of reference populations would improve the triangulation of illegally captured ...
Anesthesia and analgesia are major components of many interventional studies on laboratory animals. However, various studies have shown improper reporting or use of anesthetics/analgesics in research proposals and published articles. In many cases, it se
Uix Kit isn't a reusable component structure, mostly custom CSS and JavaScript based. Definitely interesting, and if you're developing mostly web content and not applications this is particularly useful. It is a web dev build tool/scaffold that does not depend on any framework. You can import...
This generates an initializer and scaffold files for Rails view scaffolding. Add Bootstrap imports to the top yourapplication.scss // application.scss@import"~bootstrap/scss/_functions";@import"~bootstrap/scss/_variables"; ... Now you've got Bootstrap in the application. ...
Genome scaffold anchoring and comparative genomics. The high-density, high-resolution genetic linkage map was comprised of 28,194 SNPs, which were approximate 7 fold more markers comparing with pre- vious linkage map that used for Songpu mirror carp genome assembly15. Thus, the linkage map ...
CARD11encodes a signaling scaffold protein that functions in upstream of the NF-κB pathway. Mutations in CARD11 gene leads to recurrent infections, B cell expansion, NF-κB hyper activation and T cell anergy18,19. CD19express a cell surface protein in B lymphocytes. Mutations in this gene ...