At follow up, three and a half months later there was resolution of macroglossia and all the other symptoms with restoration of euthyroid state (T3-103ng/dL, t410.7mcg/dL and TSH0.30 micro IU/mL). We report the rare presentation of primary hypothyroidism as macroglossia. Other causes of ...
AD is a progressive neural disease induced by the accumulation of toxic misfolded amyloid β-protein (Aβ) plaques in the brain. In this disease, extracellular β-amyloid plaques form in the basal, temporal, and orbitofrontal neocortex. In severe AD cases, the plaques spread to the hippocampus1...
Other internal diseases such as amyloidosis and sarcoidosis may cause skin symptoms and accompanying rashes. Lichen planus may appear as purple, itchy papules on the extremities, a large itchy plaque on the ankle, scarring hair loss, erosions in the mouth or genital area, or a combination of ...
Secondary amyloidosis is a complication of diseases characterized by recurrent acute inflammation. In this study, a standardized stimulus which induced fev... KPWJ Mcadam,RJ Elin,JD Sipe,... - 《Journal of Clinical Investigation》 被引量: 307发表: 1978年 Distinguishing hypertrophic cardiomyopathy fr...
The proportion doubled when researchers looked for extra-cardiac symptoms associated with the hereditary form of ATTR amyloidosis, suggesting under-recognition of the disease in its early stages. These symptoms included carpal tunnel syndrome (pressure on a nerve in your wrist causing tingling...
making them a fabulous addition to any family environment. Beagles are prone to several health conditions, making health screening important at an early age. Hip dysplasia,disc disease, inherited autoimmune hypothyroidism, periodontal disease, renal amyloidosis, Chinese Beagle Syndrome (MLS), and Epileps...
This is the first detailed analysis of GI manifestations in patients with ATTR amyloidosis, based on data from THAOS, and a large number (n = 1744) of subjects were available for the study. GI symptoms were generally common and often occurred early after disease onset. However, patients ...
Thus, developing agents that target common structures of oligomers assembled from different amyloids could be a promising strategy to treat one amyloidosis or several amyloidoses. PD is the second most frequent neurodegenerative disease in humans, which is characterized pathologically by the formation of...
These results extend recent findings concerning a human disease-symptom network based on 322 individual symptoms extracted from MeSH.53 We provide a CDN browser that allows users to navigate through the network of common diseases that are interconnected by phenotypic similarity (Figure S7). Download:...
Clinically the symptoms are very heterogeneous, but two major groups can be broadly recognized based on predominant recurrent infections of the respiratory tract versus inflammatory complications with a variety of autoimmune disorders (22% to 48%) including cytopenias, granulomatous disease, and increased...