Liver fat storage, also called hepatic steatosis, is increasingly common and represents a very frequent diagnosis in the medical field. Excess fat is not without consequences. In fact, hepatic steatosis contributes to the progression toward liver fibrosis. There are two main types of fatty liver di...
breakup in their personal life may bring personal challenges to their relationships with the whole family. Unlike structural therapy, systemic family therapy does not place power on one individual or a group. It may posit that identifying power roles could harm the family members' subconscious ...
Because the fruit fly genome is thoroughly mapped and understood, the group was able to target in aging fruit flies genes that are known to play important roles in the accumulation of actin filaments. That included a gene called Fhos, a member of a family of proteins known to elongate and ...
Apoliprotein E-mediated ferroptosis controls cellular proliferation in chronic lymphocytic leukemia Federica Nardi Rosita Del Prete Anna Kabanova Leukemia (2024) Genomic map of the cellular composition of the tumor microenvironment Nature Immunology (2024) Multifaceted roles of APOE in Alzheimer disease...
leading to tissue damage and lung inflammation (Verhamme et al.2019). The primary reason for the two different outcomes is the varying expression and distribution of BMP ligands and their corresponding receptors, which result in BMPs often playing different roles even though they have the same si...
Microglia are the resident, macrophagic immune cells of the CNS, with roles in surveillance and phagocytosis. TLRs on microglia recognize DAMPs and PAMPs, and these cells release inflammatory cytokines and second messengers which facilitate crosstalk with astrocytes and other immune cells (Fig.1). Bo...
Mouse models of human TB pathology: roles in the analysis of necrosis and the development of host-directed therapies. Semin Immunopathol. 2016;38:221–37. Article PubMed Google Scholar Piggott JA, Hochholzer L. Human melioidosis. A histopathologic study of acute and chronic melioidosis. Arch...
DMRTA2 has been found to regulate the expression of Hes1 gene, and this gene has been studied to have roles in cancer stem cell (CSC) maintenance, metastasis, and drug-induced apoptosis antagonism [67], [68]. The notable TF regulating the common genes between NFO and MO in TP was ...
which predicts desirable life outcomes in many domains99. Furthermore, happiness has been related to reduced mind-wandering100, which is one of the critical roles of the DMN regions101. Correspondingly, unhappy people showed increased regional functional connectivity in the DMN102, whereas more succes...
Genetic markers of striatal dopamine predict individual differences in dysfunctional, but not functional impulsivity. Neuroscience 2010; 170: 782–788. 90 White MJ, Lawford BR, Morris CP, Young RM. Interaction between DRD2 C957T polymorphism and an acute psychosocial stressor on reward-related ...