We then carried out overrepresentation analysis using https://toppgene.cchmc.org/enrichment.jsp with the background set of all protein-coding genes for which we have a gene z-score available. Results are shown in Table S3. Association with LoF and MiS intolerance MiS and LoF intolerance z-...
Lawrence W Fitzgerald, Diane T Stephenson & Mathew T Pletcher 9378 Accesses 42 Citations 2 Altmetric 1 Mention Explore all metrics Abstract Background Austism spectrum disorder (ASD) is a heterogeneous behavioral disorder or condition characterized by severe impairment of social engagement and the...
Future studies are needed to understand the dynamics of CTRC expression under stress, determining the specific single-nucleotide polymorphisms linked with altered expression, the mechanism of increased risk with alcohol and smoking, and modeling of genetic risk in the background ...
Munson, J. LawrenceBraasch, John WSurgical Clinics of North AmericaSchirmer WJ, Rossi RL, Hughes KS, Munson JL, Braasch JW. Common operative problems in hepatobiliary surgery. Surg Clin N Am 1991;71:1363-89.Common operative problems in hepatobiliary surgery. Schirmer WJ,Rossi RL,Hughes KS,et...
Background Neural tube defects (NTDs) are one of the most common birth defects, with a historical prevalence of ~1 in 1000 in the US [1, 2]. The NTD rate is now closer to ~5 in 10,000 in areas with folic acid fortification, such as the US [3] and many European countries [4]...
you will Iawe mlUlons with one special&ad audience after another. Don't try to dilate it for an imaginary audience of millloas who have 5omc vague intcrcst or who turn it on for back- ground music." Yet Reeves does not consider blmsalf aa elitist - "at Ieast sot in the pejorative...
The prospect that multiple genes tied to a single disorder converge on a common set of pathways provides hope that therapeutics can be developed that will be efficacious in a patient population with a heterogeneous genetic background.Abbreviations ASD: Autism spectrum disorder BDNF: Brain-derived ...
Manage preferencesfor further information and to change your choices. Accept all cookies Abstract Background Genetic heritability and expression study have shown that different diabetes traits have common genetic components and pathways. A computationally efficient pathway analysis of GWAS results will benefit...
The probability of both abnormalities arising completely indepen- dently in a single individual is minute, and thus, it seems likely BCR-ABL1 arose on a background of V617F-induced GI. Chronic myeloproliferative disorders compared NCP Cross et al Finally, we need to understand further mechanisms...
Background Rates of psychiatric conditions common to end-stage cancer patients (delirium, depression, anxiety disorders) remain unchanged. However, patient numbers have increased as the population has aged; indeed, cancer is a chief cause of mortality and morbidity in older populations. Effectiveness ...