We have found six variants nominally associated with BMD, of which 2WNT16variants predicted to be eQTLs forFAM3C(rs55710688, in the Kozak sequence and rs142005327, within a putative enhancer) withstood multiple-testing correction. In addition, two rare variants in functional regions (rs190011371...
Using genome-wide and exome-wide association analyses, we identify 24 loci (21 of which are novel) where germline genetic variation influences predisposition to CHIP, including missense variants in the lymphocytic antigen coding gene LY75, which are associated with reduced incidence of CHIP. We ...
Jennifer A. SmithUniversity of Michigan School of Public Health Ann Arbor MI USAMiao YuUniversity of Michigan School of Public Health Ann Arbor MI USAPriya MoorjaniUniversity of California Berkeley Berkeley CA USAAndrea GannaInstitute for Molecular Medicine Finland Helsinki FinlandAparajit Ballav Dey...
求翻译:both common and rare variants是什么意思?待解决 悬赏分:1 - 离问题结束还有 both common and rare variants问题补充:匿名 2013-05-23 12:21:38 正在翻译,请等待... 匿名 2013-05-23 12:23:18 这两种常见和罕见变种 匿名 2013-05-23 12:24:58 共同和罕见的变形 匿名 2013-05-23 ...
Fourteen genetic loci have been associated with atrial fibrillation in European and Asian ancestry groups3,4,5,6,7. To further define the genetic basis of atrial fibrillation, we performed large-scale, trans-ancestry meta-analyses of common and rare variant association studies. The genome-wide ...
A unified framework for multi-locus association analysis of both common and rare variantsCumulus-oocyte complexes (COCsIVMdurationpolar bodyactivationp pBackground/p pCommon, complex diseases are hypothesized to result from a combination of common and rare genetic variants. We developed a unified ...
Late-diagnosed ADHD had a larger genetic overlap with depression than childhood ADHD and no increased burden in rare protein-truncating variants. Overall, these results suggest a genetic influence on age at first ADHD diagnosis, persistence of ADHD and the different comorbidity patterns among the ...
We describe the genes identified in this congenital malformation and postulate that both common ‘low penetrant’ variants in combination with rare or private ‘high penetrant’ variants determine the risk on HSCR, and likely, on other complex diseases. We also discuss how new technological advances...
we propose a flexible multi-locus method based on unions of multiple SNPs that yields a test that always has only one degree of freedom. The method implicitly accounts for linkage disequilibrium and is appropriate for simultaneous analysis of common and rare variants. We demonstrate by simulation ...
Common and rare CARD14 gene variants affect the anti-TNF response among Psoriasis patients. Br J Dermatol 2016.Coto-Segura, P.; Batalla, A.; Gonzalez... P Coto-Segura,A Batalla,D González-Fernández,... - 《International Immunopharmacology》 被引量: 21发表: 2015年 gene variants and anti...