We envisage that strategies for blocking LPA signaling will be used to improve the efficacies of existing chemotherapies and radiotherapy regimens. This is based on preclinical evidence that blocking the effects of LPA increases the efficacy of taxanes, cisplatin, tamoxifen and doxorubicin in treating ...
Figure 2. OOvveerrvviieeww ooff tthhee LLPPA signaling axis. EExxttrraacceellululalarrLLPPAA iiss pprroodduucceedd ffrroomm LPCC by the lysophospholipase D activity of ATX. LPA then signals through at least six known G-protein coupled LPAA receppttoorrss to mediate its host of ...