International journal of radiation oncology, biology, physics . 2001Frykholm GJ ,Pahlman L, Glimelius B. Combied chemo- and ra- diotherapy vs. radiotherapy alone in the treatment of primary, nonresectable adenocarcinoma of the rectum[J]. Int J Radiat Oncol Biol Phys, 2001,50(2):427-434....
combined chemo and radiation therapy is considered as the first treatment of choice. However, it is unknown how to define criteria for selecting a subgroup of patients who would benefit
Numerous attempts have been made to improve the response rate and the survival of these patients with various chemoand radiotherapy schemes. Systemic chemotherapy with cisplatin/vindesine is one of the most active treatments, with a response rate of 40%, but it is limited because of its side ...
Chemo- therapy, radiotherapy and combined modality for Hodgkin's disease, with emphasis on second cancer risk. Cochrane Database Syst Rev. 2005;4:CD003187.Franklin JG, Paus MD, Pluetschow A, et al. Chemotherapy, radiotherapy and combined modality for Hodgkin's disease, with emphasis on ...
Strategies of Protection of Normal Cells During Chemo and RadioTherapy Based on Modulation of Cell Cycle and Apoptotic Pathways The ultimate goal of cancer therapy is to selectively kill cancer cells, while sparing normal cells. Therefore, major research efforts have been aimed at the discovery of ...
therapy can selectively inhibit tumor proliferation and metastasis, and patients can achieve long-term survival benefits with low toxic and side effects. Targeted therapy involves a variety of tumor mechanisms, in which combination with radiotherapy may improve radioresistance and the efficacy of ...
Radiation therapy for cancer can lead to off-target toxicity and can be ineffective against hypoxic solid tumours and distant metastases. Here, we show that intratumoral injection, in mouse and rabbit xenografts and in patient-derived mouse xenografts, of a sodium alginate formulation containing catala...
In recent years, single-cell analyses have revealed the heterogeneity of the tumour microenvironment (TME) at the genomic, transcriptomic, and proteomic levels, further improving our understanding of the mechanisms of tumour development. Single-cell RNA
Chemoradiation with hyperthermia in the treatment of head and neck cancer The management of head and neck cancer requires skilled integration of multiple modalities such as surgery, radiation, chemotherapy and hyperthermia. Chemo... NG Huilgol,S Gupta,R Dixit - 《International Journal of Hyperthermia...
Specifically, inclusion of established biomarkers like tumor size for primary radio(chemo)therapy or human papilloma virus (HPV) infection status in head and neck squamous cell carcinoma seems to be of very high relevance. The high heterogeneity of CSC subclones along with changes of the functional...