共有k次独立试验,第i次实验的P值为Pi(i = {1, 2, ..., k})。采用Fisher's method将k次独立试验的p值结合起来进行显著性检验。 公式为:∑i=1k−2lnPi∼χ2(2k)服从自由度为 2k 的χ2分布 公式推导如下: 1.1指数分布函数:F(x)=1−e−λx ...
https://en.wikipedia.org/wiki/Extensions_of_Fisher%27s_method 例子: 假设我们希望使用 Fisher 方法(默认)组合来自同一零假设的四个独立检验的 p 值。 >>>fromscipy.statsimportcombine_pvalues>>>pvalues = [0.1,0.05,0.02,0.3]>>>combine_pvalues(pvalues) SignificanceResult(statistic=20.828626352604235, ...
Stephen Turner
frac. pop 3.238342 .6912 .0070892 .7698467 -.2989599 13.59664 (exact) .9264524 (exact) 1-sided Fisher's exact P = 0.0964 2-sided Fisher's exact P = 0.0964 In this table, the one- and two-sided significance values are equal. This is not a mistake, but it does not happen often. ...
for the S + domains, which were significantly more biased toward higher CO intensities than S− for all four animals (Wilcoxon rank sum test, two-sided, P-values less than 0.05 are considered significant, and the same test method and criteria were applied on the following comparisons)....
7. A method of recovering a time multiplexed pilot signal, comprising the steps of combining a dispreading and descrambling code with a pilot code to create a combined code that is suitable for use by a single correlator to retrieve the pilot signal from a data stream. 8. A method as ...
of each T cell type’s contribution to the disease-associated difference in mitochondrial mass, showed lower mitochondrial mass of Tregs, Th2s, and Th17s as most indicative of T2D status (Figure 1F, striped bars; negative values indicate the overall mitochondrial mass is lower in T2D samples)....
Combine independent p-values using the Fisher methodCalin VoichitaSorin Draghici
To this end, we consider the minimum-p and Fisher's methods of combining P-values from linear and quadratic statistics. Extensive simulation studies show that both methods are robust across models with varying proportions of causal, deleterious, and protective rare variants, allele frequencies, and...
To this end, we consider the minimum-p and Fisher's methods of combining P-values from linear and quadratic statistics. Extensive simulation studies show that both methods are robust across models with varying proportions of causal, deleterious, and protective rare variants, allele frequencies, and...